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Specifications
| Appearance | White to yellow paste |
| Purity | 99.0% min |
| Identification (HPLC) | The retention time of major peak of sample solution corresponds to that of reference standard solution |
| XSC-R1 | 0.2% max |
| XSC-R2 | 0.1% max |
| XSC-R3 | 0.5% max |
| Individual unspecified impurity | 0.2% max |
| Total impurities | 1.0% max |
| Water | 0.5% max |
| Storage condition | Freeze (-20°C) |
Applications
Tbuo-ste-glu(aeea-aeea-OH)-Otbu is a specialized protected peptide derivative used primarily in peptide synthesis and medicinal chemistry research. Its structure features amino acid residues and linker units protected by tert-butyl (Otbu) and other protective groups, which allows selective deprotection and stepwise assembly in solid-phase peptide synthesis (SPPS). It is commonly employed as an intermediate for the preparation of peptide conjugates, modified peptides, and peptide-based drug candidates, particularly those incorporating spacers or functional linkers for targeted delivery, imaging, or receptor-binding studies. This compound is also utilized in the synthesis of bioactive peptides that require precise control over functional groups, including hydroxyl and amine termini, which are critical for subsequent modifications such as cyclization, bioconjugation, or labeling with fluorescent or therapeutic moieties. Researchers use it to generate peptide libraries, optimize linker length and flexibility, and study structure–activity relationships in peptides targeting receptors or enzymes.
Benefits
The main advantage of Tbuo-ste-glu(aeea-aeea-OH)-Otbu is its versatility and control in peptide synthesis. Protective groups such as Otbu allow selective deprotection without affecting other sensitive functionalities, ensuring high fidelity during multi-step syntheses. The presence of spacer units like aeea (aminoethoxyethoxyacetic acid) provides flexibility and improves the solubility and bioavailability of peptide derivatives. This structural design allows precise tuning of peptide length, sterics, and functional orientation, which is particularly beneficial for optimizing binding affinity, pharmacokinetics, or delivery properties of peptide-based therapeutics. The compound is compatible with automated SPPS protocols, facilitating reproducible and high-yield production of complex peptides. Its chemical stability under standard reaction conditions reduces degradation and side reactions, while the functional termini enable further modifications for conjugation or labeling, expanding its utility in drug development and biochemical research.
Conclusion
Tbuo-ste-glu(aeea-aeea-OH)-Otbu is a highly functionalized peptide intermediate that supports precise and efficient peptide synthesis. Its protective groups and linker structure allow controlled assembly, enhanced solubility, and targeted functionalization, making it ideal for research in peptide therapeutics, bioconjugates, and structure–activity studies. The compound's versatility, stability, and compatibility with automated synthesis processes make it a valuable tool in modern medicinal chemistry and peptide-based drug development, enabling the production of high-quality, functional peptide derivatives.
