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Specifications
| Appearance: | White or off-white powder | ||||||
| Purity (HPLC): | 98% min | ||||||
| Assay: | 97.0% - 103.0% (anhydrous and acetic acid free substance) | ||||||
| Solubility: | Soluble in 20% ACN/H2O | ||||||
| HPLC: | The principal peak in the chromatogram obtained with the test solution is similar in retention time to principal peak in the chromatogram obtained with the reference solution. | ||||||
| MS: | 3355.7 ± 1.0 | ||||||
| Related Substances: |
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Applications
1. Diabetes Research and Therapeutics
Used extensively in type 2 diabetes mellitus research to study insulinotropic effects.
Forms the basis for the development of GLP-1 receptor agonists and DPP-4 inhibitors.
Helps in understanding glucose-dependent insulin secretion and improving glycemic control.
2. Obesity and Metabolic Syndrome
Investigated for its role in appetite regulation and weight loss.
GLP-1(7-37) analogs are utilized in obesity treatment by promoting satiety and reducing food intake.
3. Cardiovascular Studies
Explored for cardioprotective effects, including improving heart function and reducing cardiovascular risks in diabetic patients.
4. Neuroprotective Research
Studied for potential roles in neuroprotection and cognitive function, particularly in neurodegenerative diseases.
Benefits
Potent Insulin Secretion Enhancer: Stimulates glucose-dependent insulin release, minimizing hypoglycemia risk.
Glucagon Suppression: Lowers glucagon levels, reducing hepatic glucose output.
Weight Management: Reduces appetite and promotes satiety.
Multi-Organ Benefits: Supports pancreatic beta-cell health, cardiovascular function, and possibly neuronal health.
Research Tool: Essential for studying incretin biology and designing novel antidiabetic drugs.
Conclusion
GLP-1(7-37) Acetate (CAS 106612-94-6) is a key biologically active incretin peptide involved in glucose metabolism and insulin regulation. It serves as an important research tool and therapeutic target in type 2 diabetes, obesity, and cardiovascular disease. Despite its short natural half-life, GLP-1(7-37) has paved the way for innovative treatments that improve glycemic control and support metabolic health.
