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Specifications
| Appearance: | White or off-white powder | ||||||||||||
| Solubility: | Soluble in water and 1% acetate acid | ||||||||||||
| HPLC: | The principal peak in the chromatogram obtained with the test solution is similar in retention time to principal peak in the chromatogram obtained with the reference solution. | ||||||||||||
| Amino acid analysis: |
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| MS: | 994.2 ± 1.0 | ||||||||||||
| Unspecified impurity for each impurity: | 1% max | ||||||||||||
| Purity (HPLC): | 98% min | ||||||||||||
| Acetic acid: | 7.5% max | ||||||||||||
| Water: | 7% max | ||||||||||||
| Bacterial endotoxins: | 20 IU/mg max | ||||||||||||
| Assay (anhydrous and acetic acid free substance): | 97% to 103% |
Applications
1. Preterm Labor Management
Atosiban is primarily used as a tocolytic agent to inhibit premature uterine contractions and delay preterm birth.
Helps prolong pregnancy, allowing more time for fetal development.
Improves neonatal outcomes by reducing risks associated with premature birth.
2. Research Use
Employed in studies on uterine physiology and oxytocin receptor signaling.
Used to explore the roles of oxytocin in reproduction and labor.
3. Potential Therapeutic Exploration
Investigated for possible uses in conditions where oxytocin modulation may be beneficial, such as certain psychiatric or neurological disorders.
Benefits
Effective Tocolysis: Atosiban provides targeted inhibition of uterine contractions with fewer cardiovascular side effects than other tocolytics.
Improved Neonatal Outcomes: Delays preterm labor, reducing neonatal morbidity and mortality.
Favorable Safety Profile: Generally well tolerated in pregnant women with minimal adverse effects.
Specific Mechanism: Selectively antagonizes oxytocin receptors without broadly affecting other receptors.
Rapid Onset: Provides quick inhibition of contractions upon administration.
Conclusion
Atosiban (CAS 90779-69-4) is a clinically important oxytocin receptor antagonist used as a tocolytic drug to manage preterm labor by inhibiting uterine contractions. It offers a targeted, effective, and safer alternative to other labor-suppressing agents, improving pregnancy outcomes and neonatal health. Beyond its clinical use, atosiban serves as a valuable research tool in reproductive biology and oxytocin receptor studies.
