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Specifications
| Appearance: | White or off-white powder |
| Solubility: | Soluble in H2O |
| MS: | 1142.3 to 1144.3 |
| Unspecified impurity for each impurity: | 1% max |
| Purity (HPLC): | 98% min |
| Counter Ion: | Ammonium |
Applications
1. Diagnostic Tool
Used in gallbladder function tests to evaluate biliary tract diseases.
Helps diagnose conditions such as gallbladder dyskinesia and biliary obstruction by stimulating gallbladder contraction and measuring ejection fraction.
2. Digestive Disorders
Occasionally used to stimulate pancreatic secretions in diagnostic or therapeutic settings.
Aids in understanding pancreatic exocrine function.
3. Research Applications
Serves as a tool to study gastrointestinal motility, secretion, and hormone regulation.
Used in pharmacological studies targeting CCK receptors.
Benefits
Reliable Gallbladder Stimulation: Effectively induces gallbladder contraction for functional assessment.
Pancreatic Secretion Enhancement: Promotes enzyme release aiding in digestive evaluations.
Safe and Specific: Minimal systemic effects when used in diagnostic doses.
Facilitates Accurate Diagnosis: Enables non-invasive functional testing, improving patient care.
Useful Research Agent: Assists in understanding digestive hormone pathways.
Conclusion
Sincalide (CAS 25126-32-3) is a synthetic cholecystokinin analog used primarily as a diagnostic agent to assess gallbladder and pancreatic function. Its ability to stimulate gallbladder contraction and pancreatic enzyme secretion makes it invaluable for evaluating biliary and digestive disorders. Additionally, it serves as an important research tool in gastrointestinal physiology.
