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Specifications
| Appearance | White crystalline powder |
| Assay | 99–101% |
| Water | 3% max |
| pH (1% aqueous) | 4–5 |
| Solubility (0.1M aqueous) | Colorless and clear |
| UV Absorbance (0.1M aqueous) | 260 nm: 0.05 max 280 nm: 0.04 max |
Applications
1. Biological Buffering Agent
PIPES monosodium salt is a Good's buffer, used to maintain stable pH in the near-neutral range, especially in biological and biochemical environments.
Commonly used in:
Cell and tissue culture media
Enzyme assays and protein purification
Nucleic acid handling
Immunoassays and Western blotting
2. Electrophoresis Systems
Acts as a buffer in gel electrophoresis, particularly PAGE, due to its effective buffering and low interference with biological molecules.
3. Pharmaceutical and Diagnostic Applications
Applied in drug formulation buffers, diagnostic reagents, and biologic preservation, where pH stability and biological inertness are essential.
Benefits
✅ Stable pH Near Neutral
With a pKa near 6.76, it is ideal for experiments requiring tight pH control in physiological and biochemical conditions.
✅ Low Metal Ion Binding
Has low affinity for divalent metal ions like Mg²⁺ and Ca²⁺, making it safe for enzyme and cofactor systems.
✅ Water Solubility
Easily soluble in water, allowing convenient preparation of buffer solutions.
✅ Minimal UV Absorbance
Does not interfere with UV absorbance-based measurements, supporting clean detection of DNA, RNA, and proteins.
✅ Chemically Stable
Provides excellent thermal and chemical stability, enabling reproducible experimental conditions.
Conclusion
PIPES monosodium salt (CAS 10010-67-0) is a versatile and reliable biological buffer, optimized for pH control in the 6.1–7.5 range. Its solubility, low metal ion interaction, and stability make it essential in life science research, diagnostics, biotechnology, and pharmaceutical applications, where precise, reproducible buffering is required without interference in sensitive biological processes.
