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Specifications
| Appearance | White crystalline powder |
| Assay | 99% - 101% |
| Loss on drying | 1% max |
| pH (1% aqueous) | 6.5 - 7.1 |
| Solubility (10% aqueous) | Colorless, clarity |
| Heavy metal (Pb) | 0.0005% max |
| Ultraviolet absorbance 10% aq. / 260nm | 0.05 max |
| Ultraviolet absorbance 10% aq. / 280nm | 0.05 max |
Applications
1. Biological Buffer
PIPES sesquisodium salt is a widely used Good's buffer, effective at maintaining stable pH in the near-neutral range.
Commonly employed in:
Cell culture media
Protein purification and enzyme assays
Molecular biology applications such as DNA/RNA isolation and electrophoresis
2. Pharmaceutical Research and Formulations
Used in the preparation of pharmaceutical buffers to stabilize pH-sensitive drugs and diagnostic reagents.
3. Electrophoresis
Suitable for PAGE and other electrophoretic methods, where precise pH control is critical.
4. Biochemical and Diagnostic Assays
Supports enzyme reactions and assays requiring pH around neutral.
Benefits
1. Optimal Buffering Near Physiological pH
With a pKa of approximately 6.76, it buffers effectively close to neutral pH, important for biological systems.
2. Low Metal Ion Binding
Exhibits minimal interaction with divalent cations like Mg²⁺ and Ca²⁺, preserving enzymatic function.
3. High Water Solubility
Easily soluble, facilitating buffer preparation and consistent pH maintenance.
4. Chemical Stability
Stable under laboratory and industrial conditions, ensuring reliability.
5. Low UV Absorbance
Compatible with UV spectrophotometric measurements without interference.
Conclusion
PIPES sesquisodium salt (CAS 100037-69-2) is a reliable, near-neutral pH biological buffer widely used in biochemistry, molecular biology, cell culture, and pharmaceutical applications. Its buffering capacity, stability, and low interference with biological processes make it an essential reagent for precise pH control in sensitive experimental and production settings.
