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Specifications
| Appearance | White crystalline powder |
| Purity | 99.0~101.0% |
| Water | 1% max |
| Loss on drying | 1% max |
| Solubility | Clear to slightly fuzzy colorless solution |
| pH | 7.0~8.2 |
| Heavy metals (Pb) | 0.0005% max |
| Ultraviolet absorbance / 260nm | 0.05 |
| Ultraviolet absorbance / 280nm | 0.03 |
Applications
1. Biological and Biochemical Research
TAPSO sodium salt is a Good's buffer salt form, specifically designed to maintain stable pH in neutral to slightly basic environments.
Commonly used in:
Protein purification and enzyme activity assays
Electrophoresis buffer systems (especially PAGE)
Cell-free transcription and translation systems
Nucleic acid hybridization assays
2. Cell Culture and Media Preparation
Suitable for CO₂-independent buffering in microbial and mammalian cell culture, supporting stable physiological conditions.
3. Pharmaceutical and Diagnostic Use
Used in formulations of biologics and in vitro diagnostics (IVDs) where pH control and low interference are essential.
TAPSO-Na is preferred where sodium ion compatibility is required.
4. Chromatography and Spectroscopy
Serves as a buffer in HPLC separations and spectroscopic assays, thanks to its UV transparency and chemical inertness.
Benefits
1. Precise Buffering Near Physiological pH
With a pKa of ~7.6, TAPSO-Na is ideal for buffering close to physiological pH, ensuring enzyme and protein stability.
2. Low Metal Ion Binding
Does not chelate essential metal ions like Mg²⁺ or Ca²⁺, making it compatible with metalloenzymes and cofactor-dependent reactions.
3. High Water Solubility
The sodium salt form enhances solubility, allowing for easy preparation and high buffer capacity.
4. Low UV Absorbance
Minimal absorbance at 260 and 280 nm, enabling accurate spectrophotometric analysis of nucleic acids and proteins.
5. Chemical and Thermal Stability
Resistant to degradation over time and at varying temperatures, making it suitable for long-term storage and reliable experimental performance.
Conclusion
TAPSO sodium salt (CAS 105140-25-8) is a versatile, high-performance biological buffer that ensures stable pH near neutrality, ideal for sensitive biochemical, pharmaceutical, and diagnostic applications. With excellent solubility, biocompatibility, and chemical stability, TAPSO-Na supports reproducible and interference-free conditions in a wide variety of life science and analytical procedures.
