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Specifications
| Appearance | White to off-white powder |
| Solubility | 5 mmol in 10 mL MeOH clear solution |
| Specific rotation [20/D] | +27.7 to +28.3° (C=1 in H2O) |
| Loss on drying | 1% max |
| Purity (TLC) | 98% min |
| Assay (T) | 98-102% |
Applications
L-Valinamide hydrochloride (CAS 3014-80-0) is a chiral amino acid derivative widely used as an intermediate in pharmaceutical synthesis and peptide chemistry. Its primary applications include serving as a building block for the preparation of peptides, peptidomimetics, and bioactive molecules, where the amide functionality provides stability and compatibility with peptide coupling reactions. It is particularly valuable in synthesizing L-valine-containing sequences, cyclic peptides, and small-molecule drugs, supporting research and development in medicinal chemistry, enzyme inhibitors, and therapeutic agents.
Benefits
The benefits of L-Valinamide hydrochloride stem from its chiral purity, chemical stability, and versatility in peptide and pharmaceutical synthesis. Its hydrochloride form enhances solubility and handling in aqueous and polar organic solvents, facilitating incorporation into multi-step synthetic processes. The amide group allows efficient coupling and derivatization without racemization, ensuring high fidelity in chiral synthesis. These features make it suitable for both laboratory-scale research and industrial production of pharmaceuticals, improving yields, reproducibility, and overall process efficiency.
Conclusion
In conclusion, L-Valinamide hydrochloride is a valuable chiral intermediate for peptide synthesis and pharmaceutical applications. Its chemical stability, chiral integrity, and functional versatility enable precise construction of L-valine-containing molecules and bioactive derivatives. By supporting efficient and reliable synthesis, it plays a critical role in modern medicinal chemistry and peptide-based drug development.
