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Specifications
|
Appearance |
White to off-white microcrystalline powder |
|
Assay |
99% min |
|
Melting point (M.p) |
108 to 110°C |
|
Loss on drying |
1.5% max |
|
Water |
1.0% max |
|
Specific Rotation (20/D) |
+21.5 to +22.5° (c=5, EtOH) |
|
TLC Analysis |
One spot |
Applications of Diethyl L-glutamate hydrochloride丨CAS 1118-89-4
1. Pharmaceutical and Medicinal Chemistry
Used as a chiral building block or intermediate in the synthesis of pharmaceuticals, especially peptides and amino acid derivatives.
Serves as a protected form of L-glutamic acid, useful in synthetic routes requiring ester protection of carboxyl groups.
Utilized in the development of prodrugs or modified amino acid derivatives to enhance drug delivery and bioavailability.
2. Peptide Synthesis
Employed in solid-phase peptide synthesis (SPPS) and other peptide coupling techniques.
The diethyl ester protects the carboxyl groups during peptide bond formation, allowing selective reactions on the amino group.
3. Chemical Research
Used as a reference compound and reagent in stereochemistry and organic synthesis studies.
Useful in the preparation of glutamate analogues for biochemical research, including neurotransmitter studies.
4. Biotechnology
Can be a precursor for producing modified amino acids in enzymatic or microbial synthesis.
Benefits
✅ Protected Amino Acid Derivative
Esterification of L-glutamic acid protects its carboxyl groups, increasing stability and controlling reactivity during chemical synthesis.
✅ Chirality Retained
The L-configuration is maintained, allowing for enantioselective synthesis and biological relevance.
✅ Versatile Intermediate
Facilitates synthesis of complex molecules including peptides, drugs, and amino acid analogs by providing functional group protection.
✅ Water and Solvent Solubility
Good solubility in water and organic solvents enhances its usability in various synthetic protocols.
Summary
Diethyl L-glutamate hydrochloride丨CAS 1118-89-4 is a protected amino acid ester salt widely used as an intermediate in pharmaceutical synthesis, peptide chemistry, and biochemical research. Its structural features provide stability and selectivity advantages in synthetic applications, especially in preserving the chirality and controlled reactivity of glutamic acid derivatives.
