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Specifications
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Appearance |
White to off-white powder |
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Purity (LCMS) |
98% min |
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NMR |
comply to structure |
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Optical rotation |
25±2.5 deg |
Transport Information
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Parameter |
Specification |
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UN Number |
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Class |
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Packing Group |
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H.S. Code |
2933990099306 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
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Storage |
Tightly closed. Dry. 2-8degC |
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Condition to Avoid |
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Package |
Manufacturing Information
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Parameter |
Specification |
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Capacity |
100kg/month |
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Frequency |
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Main Export Countries |
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Capacity/Batch |
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Experience |
Production since 2015 |
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Stock |
Applications of Fmoc-4-tert-butoxy-L-proline丨CAS 122996-47-8
1. Peptide Synthesis
Primarily used as a protected amino acid building block in solid-phase peptide synthesis (SPPS).
The Fmoc (9-fluorenylmethoxycarbonyl) group protects the amino function during peptide chain elongation, allowing selective deprotection.
The 4-tert-butoxy modification on the proline side chain enhances solubility and can influence the peptide's conformational properties.
Useful for synthesizing peptides with specific structural or functional requirements, including cyclic peptides and constrained conformations.
2. Pharmaceutical and Biochemical Research
Employed in the design and synthesis of bioactive peptides and peptidomimetics for drug discovery.
Helps generate peptides with improved stability, bioavailability, or target specificity.
3. Chemical Biology
Used to incorporate modified proline residues into peptides, which can affect protein folding, receptor binding, and biological activity.
Facilitates studies on the role of proline derivatives in protein structure and function.
Benefits
✅ Selective Protection
The Fmoc protecting group is base-labile, allowing easy removal under mild conditions without affecting other sensitive groups.
✅ Enhanced Peptide Stability
The tert-butoxy group on proline can improve peptide solubility and modulate conformation, influencing biological activity.
✅ Facilitates Complex Peptide Design
Enables the incorporation of modified proline residues to fine-tune peptide structure and function.
✅ Widely Compatible with SPPS Protocols
Compatible with standard Fmoc-based solid-phase synthesis techniques used in research and industry.
Summary
Fmoc-4-tert-butoxy-L-proline丨CAS 122996-47-8 is a specialized Fmoc-protected amino acid derivative used extensively in solid-phase peptide synthesis. Its combination of an Fmoc protecting group and a tert-butoxy-modified proline residue makes it valuable for producing peptides with enhanced stability and tailored conformations, supporting research in pharmaceuticals, biochemistry, and chemical biology.
