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Specifications
| Appearance | White to off-white powder |
| Purity (HPLC) | 99% min |
| Chiral purity (HPLC) | 99.0% min |
| Melting Point | 140-155 °C |
| Specific Rotation [α]20D | -4.5±1.5° (C=4 in DMF) |
| Solution test | Clear solution |
| Water (KF) | 1% max |
Applications
Fmoc-Arg(Pbf)-OH (CAS 154445-77-9) is a protected amino acid commonly used in peptide synthesis and pharmaceutical research. Its primary application is as a building block in solid-phase and solution-phase peptide synthesis, where the Fmoc (9-fluorenylmethoxycarbonyl) group protects the α-amino group of arginine, and the Pbf (2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl) group protects the guanidino side chain. These protecting groups prevent undesired reactions during peptide chain assembly, ensuring correct sequence formation and structural integrity. Fmoc-Arg(Pbf)-OH is particularly valuable for synthesizing arginine-rich peptides, bioactive sequences, and cyclic peptides used in pharmaceuticals, research, and biochemistry.
Benefits
The benefits of Fmoc-Arg(Pbf)-OH are linked to its dual protection strategy, which enables precise and efficient peptide synthesis. The Fmoc group allows selective deprotection under mildly basic conditions, while the Pbf group is stable during chain elongation but can be removed under acidic conditions, preventing side reactions of the guanidino group. This ensures high yield and purity of peptides containing arginine, including sequences that are prone to aggregation or side reactions. Additionally, its compatibility with other protected amino acids and reagents provides flexibility in multi-step peptide synthesis, making it suitable for complex bioactive and therapeutic peptides.
Conclusion
In conclusion, Fmoc-Arg(Pbf)-OH is an indispensable intermediate in modern peptide synthesis. Its dual protection of the α-amino and guanidino groups enables accurate, high-purity construction of arginine-containing peptides. By supporting efficient and controlled peptide assembly, it plays a critical role in the development of bioactive molecules, pharmaceuticals, and advanced peptide-based research.
