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Specifications
| Appearance | White to off-white powder |
| Purity (HPLC) | 99% min |
| Water (KF) | 1.0% max |
| Specific Rotation [20/D] | -7.0 ± 1.0° (C=1, 1N HCl) |
Applications
O-Benzyl-D-serine (CAS 10433-52-0) is a chiral amino acid derivative widely used as an intermediate in pharmaceutical and chemical synthesis. Its primary applications include serving as a building block for the preparation of peptide analogs, bioactive molecules, and medicinal compounds. The benzyl-protected hydroxyl group allows selective reactions at the amino and carboxyl sites without interference, facilitating the synthesis of complex molecules such as enzyme inhibitors, antiviral agents, and other therapeutic candidates. It is also employed in stereoselective synthesis where retention of the D-configuration is crucial for biological activity.
Benefits
The benefits of O-Benzyl-D-serine stem from its chemical stability, stereochemical integrity, and versatility in organic synthesis. The benzyl protection prevents unwanted side reactions, enabling high-yield and selective transformations. Its chiral D-serine backbone ensures the production of enantiomerically pure compounds, which is essential in drug development for efficacy and safety. Additionally, it is compatible with a variety of solvents and reagents, making it suitable for both laboratory-scale and industrial-scale applications in pharmaceutical and fine chemical synthesis.
Conclusion
In conclusion, O-Benzyl-D-serine is a valuable chiral intermediate for the synthesis of peptides, bioactive molecules, and therapeutic compounds. Its protective group, stereochemical purity, and chemical versatility enable precise and efficient synthesis of complex structures. By supporting high-fidelity, scalable, and selective chemical transformations, it plays an important role in modern pharmaceutical and organic chemistry research.
