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Specifications
| Appearance: | White or off-white freeze-dried powder or loose lump substance | ||||||||||
| Assay: | 96.0% ~ 102.0% | ||||||||||
| Solubility: | Freely soluble in water and glacial acetic acid, insoluble in ether | ||||||||||
| Color reaction: | Should appear positive reaction | ||||||||||
| Identification: | Retention time of main peak of test sample should be consistent with reference substance | ||||||||||
| Specific rotation: | -66.0° ~ -76.0° | ||||||||||
| pH: | 5.0 ~ 7.0 | ||||||||||
| Water: | 10.0% max. | ||||||||||
| Acetic acid: | 5.0% ~ 12.0% | ||||||||||
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| TAMC: | 100 CFU/g max. | ||||||||||
| TYMC: | 10 CFU/g max. | ||||||||||
| Bile-Tolerant Gram-Negative Bacteria: | Not detectable | ||||||||||
| Pseudomonas aeruginosa: | Not detectable | ||||||||||
| Staphylococcus aureus: | Not detectable | ||||||||||
| Bacterial endotoxin: | 100 EU/mg max. | ||||||||||
| Amino acids: |
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Transport Information
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2933990099306 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
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Storage |
Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20 °C |
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Manufacturing Information
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Experience |
Production since 2015 |
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Applications
1. Treatment of Acromegaly
Used to suppress excessive growth hormone (GH) secretion in patients with acromegaly.
Helps normalize insulin-like growth factor 1 (IGF-1) levels.
Controls symptoms such as enlarged hands, feet, and facial features.
2. Management of Neuroendocrine Tumors
Controls hormone-related symptoms (e.g., flushing, diarrhea) in patients with carcinoid tumors and vasoactive intestinal peptide tumors (VIPomas).
Inhibits tumor hormone secretion and may slow tumor growth.
3. Control of Gastrointestinal Bleeding
Used off-label for managing bleeding esophageal varices due to its vasoconstrictive properties.
4. Other Endocrine Disorders
Sometimes used to treat thyrotropin-secreting pituitary adenomas and other hormone-secreting tumors.
Benefits
Potent Hormone Inhibitor: Effectively reduces secretion of GH, insulin, glucagon, and other hormones.
Prolonged Duration: Longer half-life compared to native somatostatin allows less frequent dosing.
Symptom Control: Improves quality of life by alleviating symptoms caused by hormone hypersecretion.
Tumor Growth Inhibition: Exhibits antiproliferative effects on certain neuroendocrine tumors.
Multiple Administration Routes: Available as subcutaneous injection and long-acting depot formulations.
Conclusion
Octreotide Acetate (CAS 83150-76-9) is a clinically valuable somatostatin analog used primarily to treat acromegaly and neuroendocrine tumors by inhibiting hormone secretion and controlling symptoms. Its longer half-life and potent activity make it an essential drug in endocrinology and oncology, offering symptom relief and disease management in various hormone-related disorders.
