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Specifications
| Appearance | White to off-white powder |
| Content | 80.0% min |
| Purity (HPLC) | 95.0% min |
| MS | In accordance with the product |
| IR identification | In accordance with the product |
| Melting Point | 214.8-215.5℃ |
| Water Content | 7.0% max |
| Lead | 10 ppm max |
| Arsenic | 2 ppm max |
| Cadmium | 5 ppm max |
| Mercury | 1 ppm max |
| Total colony count | 1000 cfu/g max |
| Total number of molds and yeasts | 100 cfu/g max |
| Heat-resistant coliform bacteria | Not detected |
| Staphylococcus aureus | Not detected |
| Pseudomonas aeruginosa | Not detected |
Applications
N-(1-Oxohexadecyl)glycyl-L-histidyl-L-lysine (CAS 147732-56-7) is a lipidated tripeptide used primarily in biomedical and pharmaceutical research. Its structure combines a long-chain fatty acid with a histidine–lysine-containing peptide, making it valuable in drug delivery, peptide therapeutics, and biomaterials design. It is applied in the development of antimicrobial peptides, where lipidation enhances membrane affinity and antimicrobial activity. In targeted drug delivery, it can be used to improve cellular uptake and membrane permeability of peptide-based therapeutics. Additionally, it serves as a model compound for studying peptide–lipid interactions, enzyme-substrate specificity, and for designing functionalized peptides in medicinal chemistry and bioconjugation studies.
Benefits
The benefits of N-(1-oxohexadecyl)glycyl-L-histidyl-L-lysine are derived from its combined lipid-peptide structure. Lipidation improves peptide stability, increases hydrophobic interactions with cell membranes, and enhances bioavailability, allowing peptides to reach intracellular targets more effectively. The histidine and lysine residues contribute to pH responsiveness, metal ion coordination, and antimicrobial activity, providing multifunctional biological properties. Its modular design supports chemical modifications and conjugation with other molecules, enabling the development of tailored therapeutics and delivery systems. Overall, it offers improved stability, functionality, and efficacy compared with non-lipidated peptides.
Conclusion
In summary, N-(1-oxohexadecyl)glycyl-L-histidyl-L-lysine is a versatile lipidated tripeptide with applications in antimicrobial research, drug delivery, and peptide functionalization. Its benefits include enhanced membrane interaction, improved stability and bioavailability, and multifunctional biological properties. As interest in peptide therapeutics and targeted delivery systems continues to grow, this compound serves as a valuable building block and research tool for developing advanced biomedical applications.
