Hangzhou Leap Chem Co., Ltd. is one of the most professional manufacturers and suppliers of boc-l-leucine丨cas 13139-15-6 in China. Welcome to wholesale bulk high quality chemical products at competitive price from our factory. If you have any enquiry about custom service, please feel free to email us.
Specifications
| Appearance: | White to off-white powder |
| Purity (HPLC): | 98% min |
| Solubility: | 1 mmol should be clear and transparent after dissolution in 5 mL DMF |
| IR: | Consistent with structure |
| Water (KF): | 8.0% max |
| Specific rotation: | -26° to -22° (c=2, in AcOH) |
Transport Information
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H.S. Code |
2924199090305 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
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Storage |
Sealed in dry, 2-8°C |
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Condition to Avoid |
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Package |
Manufacturing Information
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Parameter |
Specification |
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Capacity |
1MT/month |
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Capacity/Batch |
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Experience |
Production since 2015 |
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Stock |
Applications
1. Peptide Synthesis
Boc-L-Leucine is a fundamental protected amino acid used in the assembly of peptides and proteins.
The Boc group protects the amino group, preventing undesired side reactions during coupling steps.
Used in Boc-based peptide synthesis strategies, often in solution-phase or solid-phase protocols.
2. Organic Synthesis
Acts as a chiral building block or intermediate in the synthesis of chiral auxiliaries, catalysts, or bioactive molecules.
Employed in the preparation of non-natural amino acids or derivatives with modified properties.
3. Pharmaceutical Research
Used in the development of peptide-based drugs, enzyme inhibitors, and ligands.
Helps explore structure-activity relationships (SAR) in medicinal chemistry.
Benefits
✅ Protection of Amino Group
The Boc group is stable under neutral and basic conditions but can be selectively removed under acidic conditions (e.g., trifluoroacetic acid), facilitating stepwise synthesis.
✅ Chiral Purity
Derived from natural L-leucine, ensuring correct stereochemistry in peptide chains.
✅ Commercial Availability
Available in high purity and bulk quantities for both research and industrial peptide synthesis.
✅ Compatibility
Compatible with a wide range of coupling reagents and deprotection protocols.
Conclusion
Boc-L-Leucine (CAS 13139-15-6) is an indispensable reagent in peptide synthesis and organic chemistry, providing amino group protection with a readily removable Boc group. Its use allows for precise and efficient construction of peptides and complex bioactive molecules, making it a staple in synthetic and medicinal chemistry laboratories.
