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Specifications
| Appearance | White or off-white powder |
| Assay | 99% min |
| Identification | IR & H1-NMR |
| Water content (KF) | 4.0% max |
| Residue on ignition | 0.5% max |
| Heavy metals | 20ppm max |
| Related substance | 1.0% max |
| Individual impurity | 0.5% max |
Applications
1. Pharmaceutical Use
Antihypertensive agent:
Ketanserin is a 5-HT₂A serotonin receptor antagonist with α₁-adrenergic blocking properties.
Used to treat mild to moderate hypertension by causing vasodilation.
Peripheral vascular disease:
Beneficial in conditions like Raynaud's phenomenon and intermittent claudication by improving blood flow.
2. Research Applications
Neuropharmacology:
Commonly used in receptor binding studies to explore serotonin (5-HT) pathways.
Helps in the understanding of psychiatric and cardiovascular diseases.
Cardiovascular studies:
Evaluated for effects on platelet aggregation, vascular resistance, and heart rate modulation.
3. Potential Investigational Uses
Investigated for roles in treating glaucoma, migraine, and psychotic disorders due to its serotonin antagonism.
Benefits
✅ Selective 5-HT₂A Antagonist
Reduces side effects compared to non-selective antihypertensives.
✅ Dual Mechanism of Action
Also blocks α₁-adrenergic receptors, enhancing its blood pressure-lowering effects.
✅ Research-Grade Tool
Reliable standard for in vitro and in vivo serotonin receptor studies.
Conclusion
Ketanserin tartrate (CAS 83846-83-7) is a valuable compound both as a therapeutic agent for managing hypertension and vascular conditions, and as a research tool in neuropharmacology. Its high selectivity for 5-HT₂A receptors and additional adrenergic antagonism make it a widely used molecule in clinical and academic research settings.
