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Specifications
| Appearance: | White solid powder |
| Purity: | 98% min |
| Solubility in water: | Clear solution |
| Water: | 0.5% max |
| Identification: | HNMR |
Applications
1. Biochemical Research
Substrate for Butyrylcholinesterase (BChE) Assays:
Widely used in enzymology to measure the activity of butyrylcholinesterase and related cholinesterases. The hydrolysis of butyrylthiocholine iodide by these enzymes releases thiocholine, which can be quantified spectrophotometrically using Ellman's reagent (DTNB).
Neuroscience Studies:
Serves as a probe in studies investigating cholinergic neurotransmission, enzyme kinetics, and inhibitor screening.
2. Drug Discovery
Used to evaluate potential cholinesterase inhibitors, which are important in treating neurological disorders like Alzheimer's disease and myasthenia gravis.
3. Toxicology
Employed to test the effects of neurotoxic agents and pesticides that inhibit cholinesterase enzymes, enabling assessment of exposure risks.
4. Diagnostic Kits
Included in diagnostic kits for determining cholinesterase activity levels in clinical samples (blood or serum), which can indicate liver function or exposure to organophosphates.
Benefits
✅ High Specificity
Selective substrate for butyrylcholinesterase, enabling precise enzyme activity measurements.
✅ Stable and Easy to Handle
Solid form with good stability, making it convenient for laboratory use.
✅ Sensitive Detection
When coupled with Ellman's reagent, it allows sensitive and rapid spectrophotometric detection of enzyme activity.
✅ Facilitates Drug Screening
Enables high-throughput screening of cholinesterase inhibitors for therapeutic development.
✅ Relevance to Neurological Research
Provides insights into cholinergic function and related disease mechanisms.
Conclusion
Butyrylthiocholine iodide (CAS 1866-16-6) is a key biochemical reagent widely used for assaying butyrylcholinesterase activity in research, drug discovery, toxicology, and clinical diagnostics. Its role as a selective substrate enables accurate measurement of enzyme kinetics and inhibitor potency, which is critical for understanding cholinergic system function and developing treatments for neurodegenerative diseases. Thanks to its stability and compatibility with colorimetric assays, it remains an essential tool in enzymology and neuropharmacology laboratories worldwide.
