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Specifications
| Appearance: | Red to brown solid |
| Assay (Carbon spectrum): | 85% min |
| Water: | 1.0% max |
Applications
1.1 Biochemical Research Inhibitor
Aurintricarboxylic acid is widely used as a potent inhibitor of nucleases, such as ribonuclease (RNase) and deoxyribonuclease (DNase).
It protects nucleic acids from enzymatic degradation during molecular biology experiments.
1.2 Antiviral Agent
Exhibits inhibitory activity against viral replication enzymes, including reverse transcriptase and RNA polymerases.
Studied for activity against viruses such as HIV, influenza, and SARS-CoV.
1.3 Apoptosis and Signal Transduction Modulation
Used to inhibit enzymes and proteins involved in programmed cell death (apoptosis) pathways.
Blocks interactions in signaling cascades related to cytoskeletal rearrangement and protein synthesis.
1.4 Protein-Nucleic Acid Interaction Studies
Interferes with protein-nucleic acid binding, useful in understanding transcription, translation, and repair mechanisms.
Employed to study topoisomerases and nucleic acid-processing enzymes.
1.5 Research Tool in Cellular Studies
Used as a tool compound to probe cellular processes such as RNA stability, DNA repair, and enzyme inhibition.
Helps elucidate molecular mechanisms underlying disease states and drug actions.
Benefits
2.1 Strong and Broad Enzyme Inhibition
Effectively inhibits a wide range of nucleases, making it invaluable for protecting DNA and RNA in sensitive assays.
Its broad-spectrum activity helps preserve nucleic acid integrity in complex biological samples.
2.2 Multifunctional Research Tool
Its ability to disrupt protein-nucleic acid interactions allows it to be used in diverse research fields including virology, molecular biology, and pharmacology.
2.3 Water Solubility
Soluble in aqueous buffers, facilitating its use in biological and biochemical systems without requiring organic solvents.
2.4 Potential Therapeutic Uses
Ongoing research suggests aurintricarboxylic acid may have therapeutic potential in antiviral treatments and cancer therapies due to its enzyme inhibition properties.
Conclusion
Aurintricarboxylic acid (CAS 4431-00-9) is a versatile and powerful biochemical reagent predominantly used as a nuclease inhibitor to protect nucleic acids during molecular biology experiments. Its broad enzyme inhibitory activity extends its utility to antiviral research, apoptosis modulation, and the study of protein-nucleic acid interactions. Water solubility and multifunctionality make it a valuable tool in diverse scientific fields. Additionally, its potential therapeutic applications continue to be explored, underscoring its importance in both basic research and drug development contexts.
