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Specifications
|
Appearance |
Colorless to yellowish clear liquid |
|
Purity (by GC) |
98.0% min |
|
Identification |
IR, NMR or retention time of gas phase detection consistent with reference substance |
|
Water content |
0.1% max |
Transport Information
|
Parameter |
Specification |
|
UN Number |
3265 |
|
Class |
8 |
|
Packing Group |
II |
|
H.S. Code |
2924199090306 |
|
Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
|
Storage |
Tightly closed. Air and light sensitive. Store under inert gas. |
|
Condition to Avoid |
Strong heating. |
|
Package |
Introduction
Ethyl nicotinoate丨CAS 614-18-6 is an ester derivative of nicotinic acid (vitamin B3) where the carboxyl group is esterified with an ethyl group. It appears as a colorless to pale yellow oily liquid with a characteristic fruity odor. This compound is notable for its vasodilatory properties and is used in pharmaceutical, cosmetic, and chemical industries.
Applications
1. Pharmaceuticals and Topical Preparations
Vasodilator: Ethyl nicotinate promotes blood flow by dilating peripheral blood vessels, enhancing microcirculation.
Used in topical formulations such as massage oils, creams, and liniments to relieve muscle stiffness, soreness, and minor aches by improving local circulation.
Acts as a counterirritant in products designed to create a warming sensation on the skin.
Sometimes incorporated in transdermal delivery systems to enhance skin permeability.
2. Cosmetics and Personal Care
Used as a penetration enhancer to improve the absorption of active ingredients in skincare formulations.
Adds a warming effect in massage oils or creams.
Occasionally utilized for its fruity aroma to modify fragrance profiles.
3. Chemical Intermediate
Employed as an intermediate in organic synthesis for the production of nicotinic acid derivatives, which are important in the development of pharmaceuticals, agrochemicals, and other fine chemicals.
4. Research and Development
Used in scientific research to study vasodilation mechanisms, skin permeability, and drug delivery.
Serves as a model compound in synthetic organic chemistry for ester reactions involving pyridine derivatives.
Benefits
1. Effective Vasodilator
Provides localized blood vessel dilation, which can aid in reducing muscle tension and promoting healing.
Offers non-invasive therapeutic benefits in topical formulations.
2. Enhances Skin Penetration
Improves delivery of active compounds through the skin barrier, enhancing efficacy of topical drugs and cosmetics.
3. Versatile Chemical Intermediate
Facilitates the synthesis of various bioactive compounds, expanding its utility beyond direct applications.
4. Pleasant Aroma
Its fruity scent contributes positively to the sensory profile of personal care products.
Summary
Ethyl nicotinoate丨CAS 614-18-6 is a valuable vasodilator ester of nicotinic acid widely used in topical pharmaceuticals, cosmetics, and as a chemical intermediate. Its ability to enhance local blood flow and skin permeability, combined with a pleasant aroma, makes it useful in products aimed at muscle relief, skin care, and drug delivery enhancement.
