M-PEG2-Azide丨CAS 215181-61-6

m-PEG2-Azide is a short-chain methoxy polyethylene glycol derivative functionalized with an azide group, widely used in bioconjugation, drug delivery, and materials science. Its azide functionality allows efficient copper-catalyzed or strain-promoted azide–alkyne cycloaddition ("click chemistry") to conjugate with alkynes on peptides, proteins, small molecules, nanoparticles, and polymers. In pharmaceutical and biomedical research, m-PEG2-Azide is employed to improve solubility, reduce immunogenicity, and enhance circulation time of therapeutics through PEGylation. It is also applied in the synthesis of hydrogels, PEGylated probes, targeted drug delivery systems, and functionalized biomaterials. Its short PEG chain provides water solubility and flexibility without introducing excessive steric bulk, making it suitable for precise molecular modifications.

The benefits of m-PEG2-Azide derive from its reactivity, biocompatibility, and controlled PEG length. The azide group enables highly selective, efficient, and orthogonal conjugation under mild conditions, facilitating precise attachment of biomolecules and materials without interfering with other functional groups. Its short PEG chain enhances solubility and reduces aggregation while maintaining minimal steric hindrance, which is critical in maintaining biological activity and target accessibility. m-PEG2-Azide is chemically stable, compatible with aqueous and organic solvents, and provides reproducible performance in both laboratory and scaled-up applications. These properties make it a versatile and reliable tool for constructing PEGylated molecules, drug delivery systems, and functional biomaterials.