1-azido-2-[2-(2-methoxyethoxy)ethoxy]ethane丨CAS 74654-06-1

1-Azido-2-[2-(2-methoxyethoxy)ethoxy]ethane is a functionalized polyethylene glycol (PEG) derivative featuring an azide group, widely used in bioconjugation, materials science, and pharmaceutical research. Its azide functionality enables efficient and selective "click chemistry" reactions, including copper-catalyzed azide–alkyne cycloaddition (CuAAC) and strain-promoted azide–alkyne cycloaddition (SPAAC), allowing conjugation with alkynes on peptides, proteins, small molecules, polymers, and nanoparticles. This compound is particularly valuable in the synthesis of PEGylated therapeutics, targeted drug delivery systems, hydrogels, and functional biomaterials, where the short PEG chain enhances solubility, reduces aggregation, and provides flexibility without significant steric hindrance. It is also applied in chemical biology for labeling, immobilization, and surface functionalization studies.

The benefits of 1-Azido-2-[2-(2-methoxyethoxy)ethoxy]ethane stem from its high reactivity, biocompatibility, and PEG-mediated solubility enhancement. The azide group enables rapid, selective, and orthogonal conjugation under mild conditions, preserving the activity of sensitive biomolecules. The triethylene glycol backbone imparts water solubility, low immunogenicity, and minimal steric interference, making it ideal for applications in drug delivery and bioconjugation. Its chemical stability and compatibility with both aqueous and organic solvents allow reproducible performance across laboratory and industrial settings. The molecule's structure facilitates controlled linker design and improves circulation and distribution of PEGylated compounds in biological systems.