MPEG5-OCH2COOH丨CAS 16142-03-3

MPEG5-OCH₂COOH is a functionalized methoxy polyethylene glycol derivative widely used in bioconjugation, drug delivery development, and advanced material engineering. With five ethylene glycol units, it provides moderate PEG chain length for enhancing water solubility and reducing aggregation of biomolecules and nanoparticles. The terminal carboxymethyl group enables efficient coupling to amines, peptides, proteins, polymers, and surfaces via EDC/NHS or other activation chemistries. MPEG5-OCH₂COOH is commonly used in the PEGylation of therapeutic peptides, enzymes, and small molecules to improve pharmacokinetics and reduce immunogenicity. It also serves as a linker or spacer in the synthesis of hydrogels, polymeric micelles, and smart drug delivery systems, contributing to improved stability, dispersibility, and functional performance. In surface modification, MPEG5-OCH₂COOH enhances hydrophilicity and minimizes nonspecific protein adsorption on nanoparticles, medical devices, and diagnostic platforms.

The benefits of MPEG5-OCH₂COOH derive from its balance of hydrophilicity, flexibility, and reactive carboxyl functionality. The PEG5 chain offers significant solubility enhancement while maintaining manageable molecular size, making it ideal for applications requiring minimal steric hindrance with improved biocompatibility. PEGylation using this reagent can extend circulation time, increase bioavailability, and reduce clearance of therapeutic agents. The carboxyl group provides controlled and reliable conjugation, enabling the production of well-defined PEGylated derivatives with reproducible properties. Its excellent stability and compatibility across aqueous and organic systems make it suitable for scalable synthesis and versatile formulation design. Additionally, MPEG5-OCH₂COOH contributes to improved colloidal stability of nanoparticles and enhanced antifouling performance in biomedical surfaces.