MPEG3-CH2COOH丨CAS 16024-60-5

mPEG3-CH₂COOH is commonly used as a functionalized polyethylene glycol (PEG) derivative in bioconjugation, pharmaceutical formulation, and materials science. Its terminal carboxylic acid group enables efficient coupling to amines, proteins, peptides, and nanoparticles through standard activation chemistries such as EDC/NHS, making it a valuable reagent for PEGylation. In drug delivery and biomedical research, it is utilized to improve solubility, biocompatibility, and circulation time of therapeutic agents. mPEG3-CH₂COOH also plays an important role in surface modification of polymers, colloids, and medical devices, enhancing hydrophilicity and reducing nonspecific adsorption. Additionally, it is used in the design of PEG-based linkers for antibody–drug conjugates (ADCs), hydrogels, and other advanced biomaterials.

The benefits of mPEG3-CH₂COOH arise from its combination of PEG solubility and reactive carboxyl functionality. Its short PEG chain (three ethylene glycol units) provides improved water solubility without significantly increasing molecular size, making it suitable when minimal steric hindrance is desired. The carboxyl group enables precise and controllable conjugation, facilitating the creation of stable, well-defined PEGylated products. PEGylation with mPEG3-CH₂COOH can enhance bioavailability, reduce immunogenicity, and extend circulation half-life of biomolecules. The compound's chemical stability, versatility, and compatibility with a wide range of solvents and biological environments make it highly reliable for formulation, surface engineering, and bioconjugation applications.