3,6,9,12,15,18-Hexaoxanonadecan-1-amine丨CAS 184357-46-8

3,6,9,12,15,18-Hexaoxanonadecan-1-amine is a polyethylene glycol (PEG)-based amine widely used in pharmaceutical, biochemical, and materials science applications. Its primary amine functionality allows it to act as a reactive building block for conjugation with carboxylic acids, activated esters, aldehydes, or other electrophiles, facilitating the synthesis of PEGylated drugs, peptides, proteins, and small molecules. The hexaethylene glycol chain improves water solubility and reduces aggregation, making it ideal for drug delivery systems, bioconjugation, and protein modification. It is also used in polymer chemistry and materials science as a hydrophilic linker or spacer for surface functionalization, hydrogels, and nanoparticle modification.

The benefits of 3,6,9,12,15,18-Hexaoxanonadecan-1-amine come from its chemical reactivity, hydrophilicity, and flexibility. The primary amine allows selective and efficient conjugation under mild conditions, preserving the activity of sensitive biomolecules. The hexaethylene glycol backbone enhances solubility, reduces steric hindrance, and provides flexibility, making it useful as a spacer in PEGylation and linker chemistry. It is chemically stable, compatible with both aqueous and organic media, and performs reliably in multi-step synthesis and bioconjugation protocols. These properties make it an effective intermediate for drug development, bioconjugation, and functional material design.