Hangzhou Leap Chem Co., Ltd. is one of the most professional manufacturers and suppliers of palmitoylethanolamide丨cas 544-31-0 in China. Welcome to wholesale custom made chemical products at competitive price from our factory. For more cheap products, contact us now.
Specifications of Palmitoylethanolamide丨CAS 544-31-0
|
Appearance: |
Fine white to off-white crystal powder |
|
Color: |
white to off white |
|
Identification: |
NMR |
|
Purity (HPLC): |
99% min |
|
Loss on drying: |
1.0% max |
|
Water: |
1.0% max |
|
Residue on ignition: |
0.1% max |
|
Lead (Pb), mg/kg: |
0.5 max |
|
Total arsenic (As), mg/kg: |
0.15 max |
|
Cadmium (Cd), mg/kg: |
2.5 max |
|
Total mercury (Hg), mg/kg: |
1.5 max |
|
Methanol: |
0.3% max |
|
Ethanol: |
0.5% max |
|
Ethyl acetate: |
0.5% max |
|
Total Plate Count: |
10,000 cfu/g max |
|
Yeast & Mold: |
300 cfu/g max |
|
Coliforms: |
10 cfu/g max |
|
E. Coli: |
negative/10g |
|
Salmonella sp.: |
negative/25g |
|
Staph Aureus: |
negative/10g |
|
Pseudomonas aeruginosa: |
negative/25g |
Overview
Palmitoylethanolamide丨CAS 544-31-0 is a naturally occurring lipid compound found in foods and produced by the body. It plays an important role in inflammation control and pain modulation, making it a popular nutraceutical and therapeutic compound.
Applications
1. Pain Management
Used as an analgesic agent in chronic and neuropathic pain conditions such as:
Sciatica
Carpal tunnel syndrome
Fibromyalgia
Diabetic neuropathy
Pelvic pain
Often used as an adjunct to conventional pain therapies to reduce the need for NSAIDs or opioids.
2. Anti-inflammatory Applications
PEA modulates inflammation by downregulating mast cell activation and inhibiting the release of pro-inflammatory cytokines.
Applied in the treatment of conditions with an inflammatory component, including:
Inflammatory bowel disease (IBD)
Multiple sclerosis (MS)
Respiratory inflammation (e.g., asthma, allergic rhinitis)
3. Neuroprotective and Cognitive Support
Shows neuroprotective effects in:
Traumatic brain injury (TBI)
Alzheimer's and Parkinson's disease models
Potential use in neurodegenerative disease support due to its anti-inflammatory and antioxidant properties.
4. Immune Modulation
Palmitoylethanolamide丨CAS 544-31-0 plays a role in regulating immune response and supporting immune homeostasis.
Studied for its ability to control immune overactivation in autoimmune and allergic conditions.
5. Dermatological and Skin Health
Used in topical formulations for skin inflammation and itching associated with:
Eczema
Psoriasis
Contact dermatitis
6. Nutraceutical and Dietary Supplement
Available as an over-the-counter supplement in many countries for general wellness, especially for:
Pain support
Stress resilience
Sleep quality improvement
Benefits
1. Natural and Endogenous
PEA is naturally synthesized in the body and found in foods like egg yolks, soy lecithin, and peanuts.
Being endogenous makes it well-tolerated and generally safe for long-term use.
2. Multi-Target Action
Acts through multiple pathways including:
PPAR-α (Peroxisome Proliferator-Activated Receptor Alpha) activation
Inhibition of mast cell degranulation
Interaction with endocannabinoid system (though not binding directly to CB1/CB2)
This broad action contributes to analgesic, anti-inflammatory, and neuroprotective effects.
3. Non-Addictive and Safe Profile
Unlike traditional pain medications, PEA is non-opioid, non-addictive, and non-sedating.
Suitable for use in chronic conditions where long-term management is required.
4. Synergistic Use
Can be combined with other natural agents (e.g., luteolin, curcumin) or pharmaceuticals to enhance efficacy or reduce side effects of conventional drugs.
Conclusion
Palmitoylethanolamide丨CAS 544-31-0 is a bioactive lipid molecule with proven benefits in pain relief, inflammation reduction, neuroprotection, and immune modulation. With a strong safety profile and natural origin, PEA is increasingly used as a therapeutic supplement and a promising adjunct in chronic disease management, especially for pain and neuroinflammation. Its multifunctional mechanism of action and tolerability make it a valuable asset in both clinical and wellness applications.
