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Specifications of 4,5,6,7-tetrahydro-5-methyl-Thiazolo5,4-cpyridine-2-carboxylic acid hydrochloride丨CAS 720720-96-7
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Appearance: |
White to yellowish powder |
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Assay (on the dried basis): |
98.0–102% |
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Identification: |
In the chromatograms of related substance determination records, the retention time of the main peak of the test substance and the reference substance should be consistent. |
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Related substances (% area Normalization by HPLC): |
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4,5,6,7-Tetrahydro-5-methylthiazolo[5,4-c]pyridine: |
2.0% max |
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Any single impurity: |
0.3% max |
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Total impurities: |
2.5% max |
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Purity: |
97.5% min |
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Water: |
1.0% max |
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Sulfated ash: |
0.5% max |
Applications of 4,5,6,7-tetrahydro-5-methyl-Thiazolo5,4-cpyridine-2-carboxylic acid hydrochloride丨CAS 720720-96-7
1. Pharmaceutical Intermediate
Primarily used as a synthetic intermediate or building block in drug discovery and medicinal chemistry.
The thiazolopyridine core is a privileged structure in medicinal chemistry, contributing to bioactivity such as:
Antimicrobial
Antiviral
Anti-inflammatory
CNS-active agents
2. Heterocyclic Compound Research
Studied in the development of novel heterocyclic scaffolds, particularly in the design of enzyme inhibitors, ion channel modulators, or receptor ligands.
Its rigid bicyclic structure supports target-specific binding affinity in biological systems.
3. Analytical and Chemical Research
Serves as a reference standard or precursor in structure–activity relationship (SAR) studies and combinatorial chemistry.
The hydrochloride form enhances solubility and stability, facilitating handling in aqueous or acidic media.
Benefits
1. Biologically Relevant Scaffold
The thiazolo[5,4-c]pyridine core is an analog to natural bioactive molecules and is often used in pharmaceutical lead optimization.
Offers potential for high receptor binding specificity and membrane permeability.
2. Synthetic Versatility
The carboxylic acid group allows for:
Amide or ester coupling
Salt formation
Prodrug development
Can be incorporated into peptide mimetics, macrocycles, or drug conjugates.
3. Improved Formulation Handling
As a hydrochloride salt, it is more stable and easier to purify and formulate than its free acid form, which is helpful in pharmaceutical R&D and early-stage formulation trials.
Conclusion
4,5,6,7-tetrahydro-5-methyl-Thiazolo5,4-cpyridine-2-carboxylic acid hydrochloride丨CAS 720720-96-7 is a specialized heterocyclic compound widely used in medicinal chemistry and drug development. Its combination of a rigid fused ring system with a functionalizable acid group and enhanced solubility as a hydrochloride salt makes it a valuable tool in the synthesis of targeted bioactive molecules.
