Hangzhou Leap Chem Co., Ltd. is one of the most professional manufacturers and suppliers of carmellose calcium(cmc-ca)丨cas 9050-04-8 in China. Welcome to wholesale bulk high quality chemical products at competitive price from our factory. If you have any enquiry about custom service, please feel free to email us.
Specifications
| Grade: | USP43 |
| Identification A: | A red-purple color develops at the interface |
| Identification B: | A white, flocculent precipitate is formed |
| Identification C: | A brown, flocculent precipitate is formed |
| Identification D: | Calcium salt reaction |
| Alkalinity: | No red color develops |
| Loss on drying: | 10% max |
| Chloride: | 0.3% max |
| Sulfate: | 0.1% max |
| Residue on ignition: | 10% to 20% |
| Particle Size: | 100% pass 100 mesh |
| Total aerobic microbial count: | 1000 cfu/g max |
| Molds and yeasts: | 100 cfu/g max |
| Escherichia coli: | Absent |
Applications
1. Pharmaceutical Applications
A. Tablet and Capsule Excipient
Disintegrant: CMC-Ca swells upon contact with water but does not dissolve, making it an ideal disintegrant. It helps break apart tablets upon ingestion, ensuring rapid drug release and bioavailability.
Binder and Filler: As a non-toxic and inert material, CMC-Ca acts as a filler in tablets and capsules and offers a good binding effect during granulation.
Controlled Release Formulations: Its swelling and gel-forming characteristics make it suitable for sustained or controlled-release drug delivery systems, especially in matrix-type tablets.
B. Oral Suspension and Emulsion Stabilizer
CMC-Ca is useful in stabilizing suspensions by preventing sedimentation of the active ingredient due to its thickening and gelling ability. It keeps particles evenly distributed throughout the liquid.
C. Dental and Mucosal Applications
In oral care products, CMC-Ca functions as a viscosity modifier and bioadhesive agent in oral gels or pastes. Its bioadhesive property improves drug residence time on mucosal surfaces.
2. Food Industry Applications
CMC-Ca is classified as a food additive (E466/E469-related family) and is particularly valued for its insoluble dietary fiber content and calcium fortification properties.
A. Dietary Fiber Supplementation
CMC-Ca acts as a non-digestible insoluble fiber, promoting gut health and improving bowel regularity. It aids in increasing fecal bulk and preventing constipation without causing fermentation or bloating.
B. Calcium Fortification
As a calcium salt, it provides a supplementary source of calcium. It is especially useful in low-fat, plant-based, or dairy-alternative products to enhance calcium content without affecting flavor or texture.
C. Texturizing Agent
While CMC-Na (sodium carboxymethylcellulose) is water-soluble and more common in texture modification, CMC-Ca offers stabilizing and anti-caking properties in powdered food formulations such as:
Instant drink powders
Meal replacement blends
Nutritional supplements
3. Cosmetic and Personal Care Applications
A. Stabilizer and Thickener
In creams, lotions, and toothpaste, CMC-Ca helps stabilize emulsions and control viscosity, ensuring uniform texture and shelf-life stability. It offers an alternative to synthetic polymers with a better safety profile.
B. Skin-Adhering Formulations
CMC-Ca's adhesive and film-forming characteristics are beneficial in face masks, patches, and wound-care gels. It enhances product adherence to skin and mucosa, improving the efficacy of active ingredients.
4. Industrial Applications
A. Detergents and Cleaning Products
Used as a soil anti-redeposition agent, CMC-Ca binds dirt particles and prevents them from settling back on fabrics. It improves washing efficiency and is preferred in eco-friendly formulations due to its biodegradability.
B. Paper and Textile Sizing
In the paper and textile industries, CMC-Ca functions as a sizing agent, improving the surface finish, strength, and printability of paper or fabric by forming a smooth coating layer.
5. Biomedical and Biotechnological Uses
A. Wound Dressing and Drug Delivery Films
Due to its biocompatibility and non-toxicity, CMC-Ca is used in biodegradable wound dressings that provide moisture control and promote healing. It can be loaded with antibacterial or therapeutic agents.
B. Scaffold Material in Tissue Engineering
Its ability to form gels and films makes it a candidate for use as a scaffold material in regenerative medicine. It supports cell growth and controlled biodegradation.
Benefits
1. Non-Toxic and Biocompatible
Safe for oral, topical, and internal use. Widely accepted in food and pharmaceutical industries.
2. High Swelling Capacity Without Dissolution
Absorbs water and swells significantly, making it ideal for use as a disintegrant, fiber source, and moisture-retaining agent.
3. Excellent Binding and Anti-Caking Properties
Binds powders and granules effectively and prevents lump formation in dry formulations.
4. Insoluble Dietary Fiber with Functional Health Benefits
Enhances gastrointestinal health without being fermented or broken down in the digestive tract.
5. Source of Calcium
Dual function as fiber and mineral source, especially valuable in nutritional supplements.
6. Stable Under a Wide pH Range
Can be used in acidic to mildly alkaline formulations without degradation or loss of function.
7. Biodegradable and Eco-Friendly
Naturally derived, environmentally friendly, and sustainable, making it suitable for green chemistry applications.
Conclusion
Carmellose calcium (CMC-Ca) is a multifunctional, biocompatible excipient and additive with a wide range of applications across the pharmaceutical, food, cosmetic, biomedical, and industrial sectors. Its unique profile - combining insoluble fiber characteristics, calcium supplementation, swelling ability, and excellent safety - makes it a valuable component in modern formulations. With increasing demand for clean-label, non-toxic, and functional ingredients, CMC-Ca is likely to gain further importance in future product development.
