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Specifications of beta.-Cyclodextrin, sulfobutyl ethers, sodium salts丨182410-00-0
|
Parameter |
Specification |
|
Grade |
USP-NF2024 |
|
Appearance |
White to off-white, amorphous powder |
|
Solubility |
Freely soluble in water, sparingly soluble in methanol, practically insoluble in ethanol, in n-hexane, in 1-butanol, in acetonitrile, in 2-propanol and in ethyl acetate |
|
Identification - IR |
Same absorption bands as USP betadex sulfobutyl ether sodium RS |
|
Identification - HPLC |
The retention time of the major peak of sample solution corresponds to the standard solution |
|
Average degree of substitution |
Conform |
|
Sodium |
Identify test are positive for Sodium |
|
Assay (on the anhydrous basis) |
95.0%~105.0% |
|
Betadex |
0.1% max |
|
1,4-butane sultone |
0.5 ppm max |
|
Sodium chloride |
0.2% max |
|
4-hydroxybutane-1-sulfonic acid |
0.09% max |
|
Bis(4-sulfobutyl) ether disodium |
0.05% max |
|
Bacterial endotoxins |
0.01 EU/mg max |
|
The total aerobic microbial count |
100 cfu/g max |
|
The total combined molds and yeasts count |
50 cfu/g max |
|
Escherichia coli |
Absence |
|
Average degree of substitution |
6.2-6.9 |
|
Peaks I-X (% peak area) |
I: 0.0~0.3 |
|
pH |
4.0-6.8 |
|
Water determination |
10.0% max |
|
Clarity of solution |
30% (w/w) solution is clear and essentially free from particles of foreign matter |
Transport Information of beta.-Cyclodextrin, sulfobutyl ethers, sodium salts丨182410-00-0
|
Parameter |
Specification |
|
UN Number |
|
|
Class |
|
|
Packing Group |
|
|
H.S. Code |
3505100000302 |
|
Stability & Reactivity |
The product is chemically stable under standard ambient conditions (room temperature). |
|
Storage |
Tightly closed. Store in a closed, dry, ventilated place |
|
Condition to Avoid |
|
|
Package |
25kg/drum |
Manufacturing Information of beta.-Cyclodextrin, sulfobutyl ethers, sodium salts丨182410-00-0
|
Parameter |
Specification |
|
Capacity |
100MT/year |
|
Frequency |
7 days |
|
Main Export Countries |
EU, US, India, Pakistan, Turkey |
|
Capacity/Batch |
1MT/batch |
|
Experience |
Production since |
|
Stock |
2,500kg |
Applications of beta.-Cyclodextrin, sulfobutyl ethers, sodium salts丨182410-00-0
Pharmaceutical Industry
beta.-Cyclodextrin, sulfobutyl ethers, sodium salts丨182410-00-0, are widely used in the pharmaceutical industry as excipients in drug formulations. These compounds are employed to enhance the solubility, stability, and bioavailability of poorly water-soluble drugs by forming inclusion complexes with active pharmaceutical ingredients (APIs).
Controlled Drug Release
Due to their ability to form complexes with drugs, beta-cyclodextrin sulfobutyl ethers are also utilized in controlled drug delivery systems. This application is particularly beneficial in improving the release profiles of drugs, allowing for sustained or targeted delivery, which enhances therapeutic outcomes.
Food and Beverage Industry
In the food industry, beta-cyclodextrin sulfobutyl ethers are used to improve the solubility of flavors, vitamins, and nutrients, as well as to mask unpleasant tastes. This helps in the formulation of better-tasting and more effective food supplements, fortifying products with active ingredients.
Cosmetics and Personal Care Products
These compounds are used in cosmetics and personal care products to enhance the stability, solubility, and efficacy of active ingredients. They are often included in skin-care, hair-care, and sun protection formulations to improve the absorption and stability of ingredients.
Environmental Applications
Beta-cyclodextrin sulfobutyl ethers can also be applied in environmental remediation, especially in removing pollutants from water and soil. Their ability to form complexes with toxic compounds helps in detoxifying environments and cleaning up hazardous waste.
Industrial and Chemical Applications
In industrial applications, these compounds are utilized as stabilizers and solubilizing agents in various chemical processes. Their inclusion enhances the performance of chemical reactions and formulations, particularly in systems where solubility or dispersion of active components is a challenge.
Benefits of beta.-Cyclodextrin, sulfobutyl ethers, sodium salts丨182410-00-0
Enhanced Solubility and Bioavailability
One of the primary benefits of beta.-Cyclodextrin, sulfobutyl ethers, sodium salts丨182410-00-0 is their ability to significantly enhance the solubility and bioavailability of hydrophobic drugs. This improves the effectiveness of medications, especially for compounds that are poorly soluble in water.
Improved Stability of Active Ingredients
These compounds can stabilize sensitive active ingredients, preventing degradation due to environmental factors like light, oxygen, and moisture. This is particularly beneficial for pharmaceutical, cosmetic, and food formulations.
Controlled and Sustained Release
By forming inclusion complexes with drugs or active ingredients, beta-cyclodextrin sulfobutyl ethers facilitate the controlled or sustained release of these substances. This allows for better therapeutic management and improved patient compliance with drug regimens.
Taste Masking and Odor Control
In food and beverage applications, they are effective in masking undesirable tastes or odors associated with certain nutrients, pharmaceuticals, or supplements. This enhances the palatability and consumer acceptance of functional food products.
Versatile Application Across Multiple Industries
From pharmaceuticals to environmental remediation, the versatility of beta-cyclodextrin sulfobutyl ethers in various sectors, including food, cosmetics, and industrial applications, makes them highly valuable and widely used.
Conclusion
beta.-Cyclodextrin, sulfobutyl ethers, sodium salts丨182410-00-0, are important compounds with diverse applications across pharmaceuticals, food, cosmetics, and industrial sectors. Their ability to enhance solubility, stability, and controlled release makes them valuable in improving the performance of active ingredients in various formulations. Their versatility and broad usage further highlight their importance in modern chemical and industrial processes.
