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Specifications of Sitagliptin丨CAS 486460-32-6
|
Appearance: |
White to off-white crystalline powder |
|
Assay (HPLC): |
99.0% ～ 101.0% |
|
Identification: |
High-performance liquid chromatography (HPLC), Infrared absorption |
|
Loss on drying: |
1.0% max |
|
Chiral impurity: |
0.15% max |
|
Any individual impurity: |
0.2% max |
|
Total impurity: |
0.5% max |
Sitagliptin丨CAS 486460-32-6 is an oral antihyperglycemic agent used primarily for the treatment of type 2 diabetes mellitus. It belongs to the class of DPP-4 (dipeptidyl peptidase-4) inhibitors, which work by increasing the levels of incretin hormones, thereby improving glycemic control in diabetic patients.
Key Applications of Sitagliptin丨CAS 486460-32-6
1. Treatment of Type 2 Diabetes
Sitagliptin is prescribed either as monotherapy or in combination with other antidiabetic drugs like metformin or sulfonylureas. It helps lower blood glucose levels by enhancing the body's natural ability to regulate insulin secretion in response to meals.
2. DPP-4 Inhibition Studies
Sitagliptin is widely used in research to study the role of DPP-4 enzymes, incretin hormones (GLP-1 and GIP), and the pancreatic β-cell response. It serves as a model compound in metabolic disease and endocrinology research.
3. Pharmaceutical Formulations
It is a key active pharmaceutical ingredient (API) in various commercial medications. Sitagliptin is often co-formulated with metformin (e.g., Janumet) to improve patient compliance and glycemic control.
4. Cardiovascular Risk Modulation (Under Research)
While primarily approved for glycemic control, sitagliptin has been studied for its cardiovascular safety profile in diabetic patients, contributing to a broader understanding of diabetes-related cardiovascular complications.
Benefits of Sitagliptin丨CAS 486460-32-6
✅ Oral Administration
Sitagliptin丨CAS 486460-32-6 is available in convenient once-daily oral formulations, enhancing patient adherence compared to injectable treatments.
✅ Weight-Neutral and Low Hypoglycemia Risk
Unlike many other diabetes drugs, sitagliptin is weight-neutral and carries a low risk of hypoglycemia when used alone.
✅ Well-Tolerated and Safe
Extensive clinical data supports sitagliptin's long-term safety, tolerability, and efficacy in managing type 2 diabetes across diverse patient populations.
