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Specifications of Sumatriptan succinate丨CAS 103628-48-4
|
Grade: |
EP9.0 |
|
Appearance: |
White or almost white powder |
|
Assay: |
97.5% – 102% (anhydrous substance) |
|
Solubility: |
Freely soluble in water, sparingly soluble in methanol, practically insoluble in methylene chloride |
|
Identification: |
IR: corresponds to Sumatriptan succinate CRS |
|
pH: |
4.5 – 5.3 |
|
Absorbance: |
0.1 max |
|
Impurity A: |
0.6% max |
|
Impurity H: |
0.3% max |
|
Impurity B, C, D: |
Each 0.5% max |
|
Impurity E: |
0.15% max |
|
Unspecified impurities: |
0.1% max |
|
Total impurity: |
0.6% max |
|
Water: |
1.0% max |
|
Sulphated ash: |
0.1% max |
|
Residual solvents: |
Methanol: 0.3% max |
Sumatriptan succinate丨CAS 103628-48-4 is the succinate salt form of Sumatriptan, a potent serotonin (5-HT1) receptor agonist primarily used in the treatment of migraine and cluster headaches. It is a cornerstone in the class of triptans, drugs specifically developed to target the pathophysiology of migraines.
Key Applications of Sumatriptan succinate丨CAS 103628-48-4
1. Migraine Treatment
Sumatriptan succinate丨CAS 103628-48-4 is most commonly prescribed for the acute treatment of migraine attacks, with or without aura. It works by stimulating serotonin receptors in the brain, which results in vasoconstriction of dilated cranial blood vessels-one of the causes of migraine pain.
2. Cluster Headache Relief
In addition to migraines, it is also used for the acute treatment of cluster headaches, a severe type of headache that occurs in cyclical patterns.
3. Pharmaceutical Formulations
Available in various dosage forms including:
● Oral tablets
● Subcutaneous injections
● Nasal sprays
● Transdermal patches
Each route is tailored to offer rapid onset of action depending on the severity and timing of migraine symptoms.
4. Research and Development
Sumatriptan succinate is also widely used in clinical studies for:
● Understanding migraine mechanisms
● Developing new delivery systems
● Comparing efficacy with newer triptans or combination therapies
Benefits of Sumatriptan succinate丨CAS 103628-48-4
✅ Fast-Acting Relief
It typically begins to alleviate symptoms within 30 to 60 minutes, especially in injectable or intranasal forms.
✅ Targeted Action
Unlike general pain relievers, Sumatriptan succinate directly targets serotonin receptors implicated in migraines, making it highly effective.
✅ Multiple Delivery Options
The availability of multiple administration routes allows tailored treatments for individuals based on symptom onset speed and patient preferences.
✅ Well-Established Safety Profile
Approved by global regulatory agencies (e.g., FDA, EMA), it has a long history of clinical use, with well-understood pharmacokinetics and efficacy.
