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Specifications of Cefotaxime sodium丨64485-93-4
|
Parameter |
Specification |
|
Grade |
USP43 |
|
Appearance |
Off-White to pale yellow crystalline powder |
|
Assay (HPLC on the anhydrous basis) |
916 ug/mg ~ 964 ug/mg |
|
Clarity and color of solution |
(1) The solution is clear in water |
|
Solubility |
Freely soluble in water, practically insoluble in organic solvent |
|
Identification |
(1) IR spectrum is concordant with RS |
|
Specific optical rotation |
+58.0°~ +64.0° |
|
pH |
4.5 ~ 6.5 |
|
Loss on drying |
3.0% max |
|
Related substances |
Deacetylcefotaxime: 1.0% max |
|
Sterility |
Meets the specifications |
|
Bacterial Endotoxins |
0.20 EU/mg max |
|
Visible particles |
No foreign matter observed on visual inspection |
|
Particulate matter |
≥10μm: 3000 pc/g max |
|
Residual solvents |
Acetone: 5000 ppm max |
|
Bulk density |
Conforms |
|
Tapped density |
Conforms |
Transport Information of Cefotaxime sodium丨64485-93-4
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Parameter |
Specification |
|
UN Number |
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|
Class |
|
|
Packing Group |
|
|
H.S. Code |
2941909099999 |
|
Stability & Reactivity |
The product is chemically stable under standard ambient conditions (room temperature). |
|
Storage |
Tightly closed. Store in a closed, dry, ventilated place |
|
Condition to Avoid |
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Package |
Manufacturing Information of Cefotaxime sodium丨64485-93-4
|
Parameter |
Specification |
|
Capacity |
250MT/year |
|
Frequency |
2 days |
|
Main Export Countries |
India, Pakistan, Bangladesh, Vietnam, Thailand, Indonesia |
|
Capacity/Batch |
300-320kg/batch |
|
Experience |
Production since 1992 |
|
Stock |
3MT |
Applications of Cefotaxime sodium丨64485-93-4
Pharmaceutical Industry
Cefotaxime sodium丨64485-93-4 is a third-generation cephalosporin antibiotic used in the treatment of bacterial infections. It is widely used in hospitals and healthcare settings to treat serious infections caused by susceptible bacteria.
Treatment of Respiratory Infections
This antibiotic is commonly prescribed for respiratory tract infections, including pneumonia and bronchitis. It is particularly effective against bacteria such as Streptococcus pneumoniae and Haemophilus influenzae.
Management of Urinary Tract Infections
Cefotaxime sodium is used to treat complicated urinary tract infections (UTIs), especially those caused by gram-negative bacteria resistant to other antibiotics.
Treatment of Septicemia and Meningitis
Due to its strong activity against a broad spectrum of bacteria, cefotaxime sodium is used in the treatment of life-threatening infections such as septicemia (blood infections) and bacterial meningitis.
Gynecological and Obstetric Infections
It is used in treating infections related to childbirth, including postpartum infections, pelvic inflammatory disease, and other bacterial complications in women's health.
Skin, Bone, and Joint Infections
Cefotaxime sodium is effective against soft tissue infections, including cellulitis, osteomyelitis (bone infections), and septic arthritis (joint infections).
Surgical Prophylaxis
In hospital settings, cefotaxime sodium is used as a preventive measure before surgeries to reduce the risk of post-surgical infections.
Benefits of Cefotaxime sodium丨64485-93-4
Broad-Spectrum Activity
Cefotaxime sodium丨64485-93-4 effectively targets a wide range of gram-positive and gram-negative bacteria, making it highly versatile in treating infections.
Effective Against Resistant Bacteria
As a third-generation cephalosporin, it is more effective against bacteria resistant to older antibiotics, providing a stronger treatment option.
Rapid Action and High Efficacy
Its ability to reach high concentrations in the bloodstream quickly makes it effective for treating severe infections with fast therapeutic action.
Low Toxicity and Good Tolerability
Compared to other antibiotics, cefotaxime sodium is generally well tolerated, with fewer side effects, making it suitable for a wide range of patients.
Intravenous and Intramuscular Administration
Its availability in both IV and IM forms allows for flexibility in hospital and emergency settings, ensuring quick and efficient delivery of treatment.
Conclusion
Cefotaxime sodium丨64485-93-4 is a critical antibiotic used to treat serious bacterial infections, particularly in hospital settings. Its broad-spectrum efficacy, ability to combat resistant bacteria, and role in treating life-threatening conditions such as septicemia and meningitis make it an essential drug in modern medicine. Its effectiveness in surgical prophylaxis and lower toxicity compared to other antibiotics further highlight its significance in healthcare.
