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Specifications of Nabumetone丨42924-53-8
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Property |
Specification |
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Appearance |
White or almost white crystalline powder |
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Assay (Anhydrous basis) |
97.0% to 102.0% |
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Solubility |
Practically insoluble in water, freely soluble in acetone, slightly soluble in methanol |
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Identification |
IR |
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Related Substances |
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Impurity F |
0.3% max |
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Unspecified Impurities |
0.10% max |
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Sum of Impurities other than F |
0.5% max |
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Water |
0.2% max |
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Sulfated Ash |
0.1% max |
Transport Information of Nabumetone丨42924-53-8
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Parameter |
Specification |
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UN Number |
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Class |
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Packing Group |
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H.S. Code |
2914509090303 |
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Stability & Reactivity |
Stable |
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Storage |
Tightly closed. Store in a closed, dry, ventilated place |
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Condition to Avoid |
formation of dust and aerosols |
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Package |
Manufacturing Information of Nabumetone丨42924-53-8
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Parameter |
Specification |
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Capacity |
1MT/month |
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Frequency |
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Main Export Countries |
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Capacity/Batch |
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Experience |
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Facilities |
Introduction
Nabumetone丨42924-53-8 is a nonsteroidal anti-inflammatory drug (NSAID) used primarily for pain relief, inflammation reduction, and arthritis management. It is a prodrug, meaning it is metabolized in the body into its active form, 6-methoxy-2-naphthylacetic acid (6-MNA), which provides its therapeutic effects.
Applications of Nabumetone丨42924-53-8
1. Treatment of Osteoarthritis and Rheumatoid Arthritis
● Long-term Pain Management:
Used to treat chronic joint pain and inflammation in arthritis patients.
● Reduces Stiffness and Swelling:
Helps improve mobility and joint function.
2. General Pain Relief and Anti-Inflammatory Effects
● Effective for Mild to Moderate Pain:
Used to relieve musculoskeletal pain, back pain, and soft tissue injuries.
● Lower Gastrointestinal Risk Compared to Other NSAIDs:
Nabumetone is less likely to cause stomach ulcers compared to other NSAIDs like ibuprofen and naproxen.
3. Potential Cardiovascular and Neurological Applications (Investigational Use)
● Explored for Neuroprotection:
Studied for its potential role in Alzheimer's disease and neuroinflammation.
● Possible Cardiovascular Benefits:
May reduce inflammation linked to heart disease and vascular disorders.
Benefits of Nabumetone丨42924-53-8
1. Long-Lasting Anti-Inflammatory Action
● Provides once or twice-daily dosing, improving patient compliance.
2. Lower Risk of Gastrointestinal Side Effects
● Unlike traditional NSAIDs, nabumetone produces less stomach irritation and ulcer risk.
3. Effective for Chronic Pain Conditions
● Used in the long-term management of arthritis and inflammatory disorders.
Conclusion
Nabumetone丨42924-53-8 is a widely used NSAID for arthritis, pain relief, and inflammation control. Its long duration of action and lower gastrointestinal side effects make it a preferred choice for chronic pain management. Additionally, ongoing research suggests potential neuroprotective and cardiovascular applications.
