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Specifications
| Appearance | White to off-white crystalline powder |
| Assay (on anhydrous basis) | 98.5% min |
| Identification | A: UV; B: HPLC |
| Water | 2.0% max |
| Individual impurity | 0.5% max |
| Specific rotation (1% solution in DMSO) | +6.0° to +9.0° |
| Total impurities | 1.0% max |
| Residue on ignition | 0.1% max |
| Optical isomer | 0.50% max |
| Heavy Metals | 20 ppm max |
Transport Information
|
Parameter |
Specification |
|
UN Number |
3077 |
|
Class |
9 |
|
Packing Group |
III |
|
H.S. Code |
2942000000 |
|
Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
|
Storage |
Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature 2 - 8 °C |
|
Condition to Avoid |
|
|
Package |
Applications
Ivabradine hydrochloride is primarily used as a cardiovascular drug to manage heart-related conditions, particularly chronic stable angina and heart failure. It works by selectively inhibiting the If ("funny") channels in the sinoatrial node, thereby reducing heart rate without affecting myocardial contractility. Ivabradine hydrochloride is commonly prescribed to patients who are unable to tolerate beta-blockers or require additional heart rate control. It is formulated in oral tablets for long-term management and is also studied in combination therapies with other cardiovascular agents to optimize treatment outcomes in patients with coronary artery disease or chronic heart failure.
Benefits
The benefits of Ivabradine hydrochloride include its ability to lower heart rate selectively, improving cardiac efficiency while minimizing effects on blood pressure and myocardial contractility. This targeted action reduces angina symptoms, improves exercise tolerance, and can decrease hospitalization rates in heart failure patients. Unlike other heart rate-lowering drugs, ivabradine does not negatively affect cardiac output, making it safer for patients with compromised cardiac function. It also provides flexibility in therapy for patients who are intolerant to beta-blockers, offering an effective alternative for heart rate management.
Conclusion
Ivabradine hydrochloride is a valuable cardiovascular medication that provides selective heart rate reduction for the management of angina and heart failure. Its benefits, including improved exercise tolerance, symptom relief, and safety in patients with compromised cardiac function, make it an important therapeutic option. By offering targeted heart rate control without compromising myocardial contractility, ivabradine hydrochloride continues to play a critical role in optimizing cardiovascular treatment outcomes.
