Hangzhou Leap Chem Co., Ltd. is one of the most professional manufacturers and suppliers of econazole nitrate丨cas 24169-02-6 in China. Welcome to wholesale bulk high quality chemical products at competitive price from our factory. If you have any enquiry about custom service, please feel free to email us.
Specifications
| Grade | EP11 / USP42 |
| Appearance | White or almost white powder |
| Appearance of Solution | The solution is clear and not more intensely coloured than reference solutions Y7 |
| Solubility | Very slightly soluble in water; soluble in methanol; slightly soluble in alcohol |
| Angle of Optical Rotation | -0.1° to +0.1° |
| Impurity A | 0.2% max |
| Impurity B | 0.2% max |
| Impurity C | 0.2% max |
| Unspecified Impurities | 0.1% max |
| Total Impurities | 0.3% max |
| Melting Point | 163°C to 167°C |
| Loss on Drying (105°C for 4 hours) | 0.5% max |
| Chlorides | 0.5% max |
| Heavy Metals | 20 ppm max |
| Sulphated Ash | 0.1% max |
| Toluene | 890 ppm max |
| Ethanol | 600 ppm max |
| Assay (On Dry Basis) | 99% to 101% |
Applications
Econazole nitrate is a broad-spectrum antifungal agent primarily used in topical formulations such as creams, lotions, and sprays to treat superficial fungal infections of the skin, including athlete's foot, ringworm, jock itch, and candidiasis. It is also effective against certain yeast infections and dermatophyte-related skin conditions. In some cases, it is used in medicated powders or solutions for preventive purposes in individuals prone to recurrent fungal infections. Beyond dermatology, econazole nitrate has been incorporated into combination therapies with corticosteroids to manage inflammation alongside fungal eradication, and in veterinary medicine, it is sometimes applied for similar antifungal purposes in animals.
Benefits
The main benefit of econazole nitrate lies in its potent antifungal activity coupled with a relatively low incidence of systemic absorption, making it suitable for localized treatment with minimal side effects. It works by disrupting the synthesis of ergosterol, an essential component of fungal cell membranes, leading to cell death and preventing the spread of infection. Its broad spectrum of activity covers dermatophytes, yeasts, and some molds, providing versatility in clinical use. Furthermore, its topical application minimizes drug–drug interactions and is generally well-tolerated even with prolonged treatment courses.
Conclusion
Econazole nitrate is a clinically important antifungal compound that combines efficacy, safety, and broad coverage against common and stubborn fungal pathogens. Its ability to deliver targeted action directly to infected areas without significant systemic exposure makes it a mainstay in dermatological antifungal therapy. With rising global incidences of fungal skin infections and the growing need for effective topical solutions, econazole nitrate remains a valuable and trusted option in both human and veterinary medicine.
