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Specifications
| Grade | EP9.0 |
| Characteristics | A white to light yellowish white powder. It is freely soluble in water, sparingly soluble in N,N-dimethylformamide, and practically insoluble in acetonitrile, in methanol, in ethanol (95), in acetone, in acetic acid(100) and in diethyl ether |
| Assay | 900IU/mg min. (anhydrous and sodium chloride-free substance) |
| Identification | Complies with stipulation in EP9.0 |
| Color and clarity of solution | Complies with the stipulation in EP9.0 |
| PH | 6.3 to 7.7 |
| Sodium chloride | 5.0% max |
| Water | 15.0% max |
| Heavy metals | 20ppm max |
| Residual solvents | Acetone: 5000ppm max |
| Composition and related substances | |
| TA2 group | 80.0% min |
| TA3 group | 15.0% max |
| Impurities | 5.0% max |
| Bacterial endotoxins | 0.31IU/mg max |
| Impurity A | 0.2% max |
Transport Information
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Specification |
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UN Number |
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Class |
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Packing Group |
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H.S. Code |
2941909099999 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
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Storage |
Tightly closed. Store in a closed, dry, ventilated place |
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Condition to Avoid |
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Package |
Manufacturing Information
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Parameter |
Specification |
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Capacity |
100kg/month |
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Frequency |
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Main Export Countries |
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Capacity/Batch |
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Experience |
Production since 2013 |
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Stock |
Applications
1. Antibiotic for Gram-Positive Infections
Teicoplanin is a potent glycopeptide antibiotic primarily used to treat serious infections caused by Gram-positive bacteria, such as:
Methicillin-resistant Staphylococcus aureus (MRSA)
Enterococcus faecalis and E. faecium
Streptococcus pneumoniae
Clostridium difficile (in some off-label oral regimens)
2. Hospital-Acquired Infections
Used in clinical settings to treat:
Sepsis
Endocarditis
Osteomyelitis
Skin and soft tissue infections
Respiratory tract infections
3. Alternative to Vancomycin
Teicoplanin is often used as an alternative to vancomycin, especially in patients with:
Vancomycin intolerance or nephrotoxicity concerns
Outpatient therapy needs, due to its long half-life
Benefits
✅ Strong Activity Against Resistant Bacteria
Effective against MRSA and other multidrug-resistant Gram-positive organisms.
✅ Long Half-Life
Allows once-daily dosing or even less frequent administration in certain cases, improving compliance and facilitating outpatient therapy.
✅ Lower Risk of Nephrotoxicity
Compared to vancomycin, teicoplanin shows less toxicity to kidneys, making it safer for long-term or high-dose therapy.
✅ Good Tissue Penetration
Achieves therapeutic concentrations in bone, heart valves, and tissues, beneficial for infections like osteomyelitis and endocarditis.
✅ Well-Tolerated
Fewer reports of infusion-related reactions (e.g., "red man syndrome") compared to vancomycin.
Conclusion
Teicoplanin (CAS 61036-62-2) is a powerful glycopeptide antibiotic valued for its efficacy against Gram-positive pathogens, especially resistant strains such as MRSA and VRE. With a favorable safety profile, long half-life, and broad spectrum of activity, it serves as a robust alternative to vancomycin in both hospital and outpatient settings. Teicoplanin's pharmacokinetic properties enable less frequent dosing, improve patient adherence, and reduce hospitalization time, making it an essential option in modern antimicrobial therapy.
