Amoxicillin Trihydrate丨CAS 61336-70-7

Amoxicillin trihydrate丨CAS 61336-70-7 is the trihydrated form of amoxicillin, a widely used β-lactam antibiotic belonging to the penicillin class. With the chemical formula C16H19N3O5S·3H2O, it is a white to off-white crystalline powder and is one of the most prescribed antibiotics globally. Amoxicillin is considered a broad-spectrum antibiotic due to its effectiveness against a variety of Gram-positive and Gram-negative bacteria.

1.Treatment of Bacterial Infections
oRespiratory Tract Infections: Amoxicillin trihydrate丨CAS 61336-70-7 is commonly prescribed for upper and lower respiratory tract infections such as pharyngitis, tonsillitis, sinusitis, bronchitis, and pneumonia. Its efficacy against Streptococcus pneumoniae, Haemophilus influenzae, and other respiratory pathogens makes it a go-to choice for general practitioners.
oEar, Nose, and Throat Infections: Especially useful in treating otitis media (middle ear infection) and sinus infections in children and adults.
oUrinary Tract Infections (UTIs): Effective against Escherichia coli and other common uropathogens.
oSkin and Soft Tissue Infections: Used for treating abscesses, cellulitis, and impetigo caused by Staphylococcus aureus and Streptococcus species.
oGastrointestinal Infections: Used in combination with other antibiotics and proton pump inhibitors to treat Helicobacter pylori infections and related peptic ulcers.
2.Dental and Oral Infections
oAmoxicillin is often used to treat dental abscesses and other oral infections due to its high oral bioavailability and rapid action against oral bacteria. It may also be used prophylactically before dental procedures in patients at risk of bacterial endocarditis.
3.Combination Therapy
oWith Clavulanic Acid: Often combined with clavulanic acid (a β-lactamase inhibitor) to form co-amoxiclav, which extends its spectrum of action by overcoming bacterial resistance mechanisms.
oH. pylori Eradication Regimens: Used with clarithromycin and a proton pump inhibitor in the triple therapy regimen for the eradication of H. pylori.
4.Veterinary Use
oAmoxicillin trihydrate is also widely used in veterinary medicine to treat infections in livestock and companion animals. It is formulated for oral and parenteral use in animals like cattle, pigs, and poultry.
5.Pharmaceutical Formulations
oAmoxicillin trihydrate is used in a wide range of formulations: tablets, capsules, chewables, oral suspensions, and pediatric syrups. Its stability in stomach acid and palatability make it particularly useful in pediatric care.

1.Broad-Spectrum Activity
oAmoxicillin trihydrate丨CAS 61336-70-7 is effective against a wide range of bacteria, including both Gram-positive and some Gram-negative organisms. This makes it a versatile first-line treatment for various common infections.
2.High Oral Bioavailability
oUnlike many other antibiotics, amoxicillin is well absorbed from the gastrointestinal tract, achieving high blood and tissue concentrations quickly. This contributes to its efficacy and rapid onset of action.
3.Excellent Safety Profile
oAmoxicillin is generally well tolerated, with a low incidence of serious side effects. It is considered safe for use in children, the elderly, and even during pregnancy when clearly needed.
4.Cost-Effective
oAs a generic medication widely available around the world, amoxicillin trihydrate is affordable for both healthcare providers and patients. This makes it a key tool in managing bacterial infections in low-resource settings.
5.Pediatric-Friendly Formulations
oThe availability of flavored suspensions and chewable tablets makes it easier to administer to children, improving adherence to treatment regimens.
6.Synergistic Use with Clavulanic Acid
oThe ability to combine with clavulanic acid significantly extends its use in treating resistant bacterial strains, allowing clinicians to tackle infections that would otherwise require more potent (and more toxic) antibiotics.
7.Low Resistance Development (When Used Appropriately)
oAlthough antibiotic resistance is a growing concern, amoxicillin still remains effective when used correctly, especially when supported by proper diagnosis and sensitivity testing.

Conclusion
Amoxicillin trihydrate丨CAS 61336-70-7 is a cornerstone antibiotic with a well-established role in the treatment of a wide range of bacterial infections. Its broad-spectrum activity, safety profile, ease of administration, and affordability make it indispensable in both human and veterinary medicine. When used appropriately, it continues to be a highly effective tool in combating infectious diseases worldwide.