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Good Product N-HATU丨CAS 148893-10-1
N-HATU, commonly known as 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate, is a specialized coupling reagent used in peptide synthesis and amide bond formation. It facilitates the activation of carboxylic acids for reaction with amines, supporting efficient preparation of peptides and other amide-containing molecules. Its role in modern coupling chemistry makes it valuable in pharmaceutical research, medicinal chemistry, and the synthesis of complex organic compounds.
Chemical Identifiers
| InChI | InChI=1S/C10H15N6O.F6P/c1-13(2)10(14(3)4)15-8-6-5-7-11-9(8)16(17)12-15;1-7(2,3,4,5)6/h5-7H,1-4H3;/q+1;-1 |
| InChI Key | FKBFHOSFPRWJNV-UHFFFAOYSA-N |
| Smiles | CN(C)C(=[N+](C)C)N1C2=C(N=CC=C2)[N+](=N1)[O-].F[P-](F)(F)(F)(F)F |
| EC No. | 604-662-7 |
| MDL No. | MFCD27957364 |
| PubChem CID | 6409673 |
Applications
Peptide Synthesis and Amide Bond Formation
N-HATU is widely used as a coupling reagent in peptide synthesis, where it supports the formation of amide bonds between protected amino acids. It can be applied in both solution-phase and solid-phase peptide synthesis, helping researchers assemble complex peptide sequences under optimized reaction conditions. Its use is particularly relevant to the preparation of research peptides and modified peptide structures.
Pharmaceutical Research and Drug Discovery
In pharmaceutical research, N-HATU supports the synthesis of amide-containing compounds and intermediates used in medicinal chemistry. Researchers may use it to prepare candidate molecules, investigate structure–activity relationships, and develop synthetic routes for complex molecular structures. Its effectiveness depends on substrate characteristics, reaction conditions, and the desired impurity profile.
Organic Synthesis and Amide Coupling
Modified Peptides and Specialized Molecules
N-HATU may be used in the preparation of cyclic peptides, peptide conjugates, and other structurally complex compounds requiring controlled amide bond formation. In combination with suitable protecting-group strategies and reaction conditions, it can support the synthesis of molecules investigated in pharmaceutical, biochemical, and chemical research.
