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Best Price Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate丨CAS 56602-33-6
Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate, commonly known as the BOP reagent, is a specialized coupling reagent used in peptide synthesis and organic chemistry. It facilitates carboxylic acid activation for amide bond formation, supporting the preparation of peptides and other nitrogen-containing organic compounds. Its role in coupling reactions makes it relevant to pharmaceutical research, medicinal chemistry, and the synthesis of structurally complex molecules.
Chemical Identifiers
| InChI | InChI=1S/C12H22N6OP.F6P/c1-15(2)20(16(3)4,17(5)6)19-18-12-10-8-7-9-11(12)13-14-18;1-7(2,3,4,5)6/h7-10H,1-6H3;/q+1;-1 |
| InChI Key | MGEVGECQZUIPSV-UHFFFAOYSA-N |
| Smiles |
CN(C)[P+](N(C)C)(N(C)C)ON1C2=CC=CC=C2N=N1.F[P-](F)(F)(F)(F)F |
| EC No. | 260-279-1 |
| MDL No. | MFCD00011948 |
| PubChem CID | 151348 |
Applications
Peptide Synthesis and Peptide Bond Formation
The BOP reagent is used in peptide chemistry to promote the coupling of protected amino acids and the formation of peptide bonds. It supports the assembly of peptide sequences in solution-phase synthesis and other suitable synthetic workflows. Researchers may use it to prepare research peptides, modified peptides, and peptide-derived compounds, with reaction conditions selected according to the target sequence and substrate properties.
Pharmaceutical Research and Drug Discovery
In pharmaceutical research, the BOP reagent can support the preparation of amide-containing intermediates and candidate compounds for medicinal chemistry studies. It is useful in synthetic routes involving the coupling of carboxylic acids with amines, enabling researchers to construct molecular frameworks for further characterization and biological evaluation. Its suitability depends on the target structure, reaction conditions, and impurity-control requirements.
Organic Synthesis and Amide Coupling
Synthesis of Complex Molecular Structures
The BOP reagent may be incorporated into synthetic workflows for preparing cyclic peptides, peptide derivatives, and other molecules that require controlled bond formation. It can support multi-step organic synthesis where amide linkages are important structural features. Its application is determined by the functional groups present in the substrate and the requirements of the overall synthetic route.
