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Specifications of Dicyclohexylcarbodiimide丨CAS 538-75-0
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Appearance |
White or light yellow crystalline or transparent liquid |
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Content |
99% min |
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Melting Point |
32℃ to 36℃ |
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Residue on Ignition |
0.1% max |
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Insoluble Matter in Acetone |
None |
Transport Information of Dicyclohexylcarbodiimide丨CAS 538-75-0
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Parameter |
Specification |
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UN Number |
2922 |
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Class |
8 |
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Packing Group |
II |
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H.S. Code |
2925290090 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
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Storage |
Tightly closed. Store in a closed, dry, ventilated place |
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Condition to Avoid |
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Package |
Manufacturing Information of Dicyclohexylcarbodiimide丨CAS 538-75-0
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Parameter |
Specification |
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Capacity |
20,000MT/year |
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Frequency |
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Main Export Countries |
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Capacity/Batch |
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Experience |
Production since 2001 |
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Stock |
Applications of Dicyclohexylcarbodiimide丨CAS 538-75-0
1. Peptide Synthesis
Primary use: Dicyclohexylcarbodiimide丨CAS 538-75-0 is a dehydrating agent widely used in the solid-phase and solution-phase synthesis of peptides.
It activates carboxylic acid groups to form amide bonds with amines, producing dipeptides and oligopeptides.
Often used with additives like HOBt (1-hydroxybenzotriazole) or NHS (N-hydroxysuccinimide) to improve yields and reduce racemization.
2. Esterification and Amidation
DCC is used to activate carboxylic acids for esterification with alcohols and amidation with amines.
Applicable in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals.
3. Crosslinking and Polymer Chemistry
Used in polymer modification and crosslinking reactions to enhance material properties.
Helps link polymers with carboxyl and amine functionalities.
4. Nucleic Acid and Bioconjugation
Utilized in biochemistry to conjugate DNA, RNA, or proteins to surfaces or fluorescent tags, especially for biosensor or imaging applications.
5. Other Organic Reactions
Serves as a coupling agent in various condensation reactions, especially when water must be removed from the reaction environment.
Benefits
1. Highly Efficient Dehydrating Agent
DCC efficiently removes water in condensation reactions, making it ideal for amide and ester bond formation.
2. Mild Reaction Conditions
Enables coupling reactions under relatively mild temperatures and neutral pH, preserving sensitive functional groups.
3. Wide Compatibility
Effective with a wide range of carboxylic acids, alcohols, and amines in both aqueous and non-aqueous systems.
4. Reagent of Choice in Peptide Chemistry
A standard in peptide coupling, especially in academic and industrial peptide synthesis.
Summary
Dicyclohexylcarbodiimide丨CAS 538-75-0 is an essential coupling reagent and dehydrating agent, widely employed in peptide synthesis, esterification, and organic transformations. Its ability to facilitate amide bond formation under mild conditions has made it a staple in both synthetic organic and biochemistry labs. With proper handling and purification strategies, DCC offers a high-efficiency route to complex molecules and functional materials.
