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Specifications
| Appearance | White to off-white powder |
| HPLC Purity | 99% min |
| Any single impurity | 0.5% max |
| 3IPNMR Purity | 98% min |
| P(III) Impurities (100-170 ppm) | 0.5% max |
| Solubility Clarity | 0.2 M solution in acetonitrile is free from undissolved particulate |
| Identity (by 1HNMR) | To conform structure |
| Residual Solvent | 3% max |
| Moisture | 0.5% max |
Transport Information
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H.S. Code |
2934999099305 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
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Storage |
Keep container tightly closed in a dry and well-ventilated place. Store in cool place. Storage stability Recommended storage temperature -20 °C |
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Condition to Avoid |
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Manufacturing Information
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Capacity |
50kg/month |
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Experience |
Production since 2017 |
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Stock |
Applications
Bz-rA Phosphoramidite is primarily used in the synthesis of oligonucleotides and RNA sequences in molecular biology and pharmaceutical research. It serves as a protected adenine nucleotide building block in solid-phase synthesis, allowing precise incorporation into RNA strands. The benzoyl (Bz) protection on the adenine base prevents undesired side reactions during synthesis, ensuring high fidelity and yield. This compound is applied in the development of antisense oligonucleotides, RNA therapeutics, gene probes, and molecular diagnostics, as well as in research focused on RNA structure and function.
Benefits
The benefits of Bz-rA Phosphoramidite include its stability, high reactivity, and compatibility with automated oligonucleotide synthesizers. The benzoyl protection ensures selective reactions, reducing impurities and enhancing overall synthesis efficiency. Its use enables precise sequence control, allowing researchers to design RNA molecules with specific functional or therapeutic properties. Additionally, it contributes to reproducible synthesis, high yield, and reliable incorporation of adenine residues, which is critical for the performance of RNA-based therapeutics and analytical tools.
Conclusion
Bz-rA Phosphoramidite is a crucial building block in RNA synthesis, supporting the production of high-fidelity oligonucleotides for research, diagnostics, and therapeutics. Its stability, reactivity, and protective functionality make it indispensable for RNA-based applications. By enabling precise, efficient, and reproducible nucleotide incorporation, Bz-rA Phosphoramidite continues to play a vital role in molecular biology and pharmaceutical development.
