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Specifications
| Appearance: | Off-white to white powder |
| Clarity of Solution: | 0.2M solution in acetonitrile is free from undissolved particulate |
| HPLC Purity: | 98% min |
| 31 P NMR Purity: | 98% min |
| Water: | 0.3% max |
| Residual Solvent: | 3% max |
| Material Origin: | No known animal-derived materials were used in the manufacture of this product |
Applications
1. Synthetic RNA Oligonucleotide Production
Used extensively in the chemical synthesis of RNA oligonucleotides, particularly those containing 2′-O-methyladenosine modifications.
The protective groups allow stepwise assembly of RNA strands with high fidelity and control.
Enables the creation of modified RNA sequences for research or therapeutic purposes.
2. RNA Therapeutics and Research
Integral in producing modified mRNA, siRNA, antisense oligonucleotides (ASOs), and aptamers with improved stability and function.
2′-O-methyl modifications help enhance RNA resistance to nucleases and reduce immunogenicity.
Useful in studying RNA structure-function relationships and protein interactions.
3. Epitranscriptomics and Molecular Biology
Facilitates the synthesis of RNA molecules mimicking natural epitranscriptomic modifications.
Helps investigate how modifications affect translation, splicing, and RNA-protein interactions.
Benefits
Enhanced RNA Stability: The 2′-O-methyl modification incorporated via this building block improves the stability of RNA against enzymatic degradation.
Reduced Immunogenicity: Modified RNA oligonucleotides synthesized with this phosphoramidite show lower activation of immune sensors.
High Synthesis Fidelity: Protective groups enable efficient, high-yield RNA synthesis with precise incorporation of modified nucleotides.
Versatility: Enables creation of custom RNA molecules for therapeutic development, molecular probes, and structural studies.
Conclusion
5-O-DMT-2-O-Me-rA(N-Bz)-3-CEDPA (CAS 110782-31-5) is a protected phosphoramidite derivative of 2′-O-methyladenosine, crucial for solid-phase synthesis of chemically modified RNA oligonucleotides. It enables researchers and pharmaceutical developers to produce stable, functional RNA molecules with applications in RNA therapeutics, epitranscriptomics, and molecular biology research. Its specialized protecting groups and chemical modifications ensure high fidelity, improved RNA stability, and reduced immunogenicity in synthetic RNA products.
