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Specifications
| Appearance: | White to Off-White Powder |
| Purity: | 98.0% min |
| Water Content: | 8.0% max |
Applications
1. RNA and Epitranscriptomics Research
Used as a standard or reference compound in studying RNA modifications, particularly 2′-O-methylation, which is common in ribosomal RNA (rRNA), transfer RNA (tRNA), and messenger RNA (mRNA).
Helps understand post-transcriptional modifications affecting RNA stability, folding, and interactions.
2. Molecular Biology and Biochemistry
Employed in synthetic RNA oligonucleotides to mimic natural RNA modifications for structural studies.
Used in enzyme assays to study the activity of methyltransferases that catalyze 2′-O-methylation.
Important for elucidating mechanisms of RNA processing, translation, and immune evasion by viruses.
3. Pharmaceutical and Therapeutic Research
Incorporated into modified RNA therapeutics and vaccines to enhance RNA stability and reduce immunogenicity.
Plays a role in designing mRNA vaccines and siRNA molecules to improve efficacy and reduce unwanted immune responses.
4. Diagnostic and Analytical Tools
Utilized in mass spectrometry and nucleoside analysis to detect and quantify methylated RNA nucleosides.
Serves as a marker for epitranscriptomic profiling in various biological samples.
Benefits
1. Enhances RNA Stability
The 2′-O-methyl modification protects RNA molecules from degradation by nucleases, increasing their lifespan in biological systems.
2. Modulates RNA Function
Influences RNA folding and interaction with proteins, impacting processes like translation efficiency and ribosome function.
3. Reduces Immunogenicity
Modified nucleosides like 2-O-methyladenosine help synthetic RNA evade innate immune detection, improving the safety of RNA-based drugs and vaccines.
4. Key Tool in Epitranscriptomics
Enables detailed study of RNA modifications, crucial for understanding gene expression regulation beyond DNA sequence.
Conclusion
2-O-Methyladenosine (CAS 2140-79-6) is a naturally occurring, methylated nucleoside with significant roles in RNA biology and epitranscriptomics research. It is widely used to study RNA structure, function, and modifications, and is instrumental in the development of stable, less immunogenic RNA therapeutics and vaccines. Its importance in understanding post-transcriptional gene regulation makes it a critical compound in molecular biology and pharmaceutical research.
