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Specifications
| Appearance: | Yellow powder |
| Purity (HPLC): | 95% min |
| Absorption Spectrum: | Stated |
| Fluorescence Spectrum: | Stated |
| Identity: | Correct wavelengths of absorbance and fluorescence peaks |
Applications
1. Fluorescent Labeling and Bioconjugation
The amino group allows covalent attachment to molecules containing activated esters or carboxyl groups, such as proteins, peptides, and nucleic acids.
Used to prepare fluorescent conjugates for cell imaging, flow cytometry, and fluorescence microscopy.
2. Fluorescent Probes and Sensors
Incorporated into fluorescent sensors for detection of metal ions, pH changes, or enzymatic activity.
Used in biosensors where fluorescence intensity changes report analyte presence.
3. Surface and Material Functionalization
Immobilized onto surfaces, polymers, nanoparticles, or hydrogels for creating fluorescent materials used in diagnostics or imaging.
4. Analytical Chemistry
Used in fluorescence-based assays for sensitive detection of biomolecules.
Applicable in enzyme activity assays and binding studies.
Benefits
1. Reactive Amino Group
The amino group enables flexible and specific chemical conjugation under mild conditions.
Facilitates the creation of stable fluorescent conjugates.
2. Strong Fluorescence
Emits bright green fluorescence with high quantum yield, suitable for sensitive detection.
3. Water Solubility and Biocompatibility
Soluble in aqueous buffers and compatible with biological environments.
Generally low toxicity at working concentrations.
4. Photostability
Good photostability allows for prolonged imaging and analysis.
Conclusion
6-Aminofluorescein (CAS 51649-83-3) is a valuable fluorescent dye derivative combining the bright fluorescence of fluorescein with a reactive amino group at the 6-position. This enables its widespread use in bioconjugation, fluorescent sensing, materials functionalization, and analytical assays, making it a versatile tool in biomedical research, diagnostics, and fluorescence imaging.
