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Specifications
| Grade: | USP41 |
| Appearance: | Light pink coloured powder |
| Identification A: | To pass test |
| Identification B: | To pass test |
| Assay (on dry basis): | 98% to 102% |
| Water: | 6% to 9% |
| Chloride: | 0.05% max |
| Sulfate: | 0.2% max |
| Arsenic: | 3 ppm max |
| Lead: | 10 ppm max |
| Heavy metals: | 20 ppm max |
| Reducing substances: | 1% max |
| Organic volatile impurities: | Meets requirements |
| Manganese content (as dihydrate): | 11.19% to 11.64% |
| Particle size (Thru 60 mesh): | 90% |
| Total aerobic count: | 1000 cfu/g max |
| Total molds-yeasts: | 300 cfu/g max |
| E. Coli and Salmonella: | Absent |
Applications
1. Nutritional and Dietary Supplements
Used in multivitamin/mineral tablets, capsules, powders, and liquids.
Helps prevent or correct manganese deficiency, which can affect bone formation, metabolism, and antioxidant activity.
2. Food Fortification
Incorporated into functional foods, beverages, infant formula, and animal feed as a trace mineral additive.
Supports dietary intake of manganese in populations with increased requirements or poor nutritional status.
3. Pharmaceutical Preparations
Used in oral and parenteral formulations to treat or manage manganese deficiency, especially in patients receiving long-term intravenous nutrition.
Included in trace element solutions for clinical and hospital use.
4. Cosmetics and Personal Care
May be added to skin creams and hair products for its role in enzyme activation and antioxidant defense, though use is limited compared to zinc or copper gluconates.
5. Veterinary and Agricultural Use
Added to livestock and poultry feed to support reproductive health, bone development, and immune function.
Used in fertilizers to correct manganese-deficient soils, improving crop yield and quality.
Benefits
1. Essential Trace Mineral for Enzyme Activation
Manganese is a cofactor for several key enzymes including:
Superoxide dismutase (MnSOD) – protects against oxidative damage.
Arginase, pyruvate carboxylase, and glycosyltransferases – involved in metabolism, bone formation, and wound healing.
2. Supports Bone and Joint Health
Manganese is involved in the formation of bone matrix and cartilage.
Plays a role in collagen production and may support joint health when combined with other minerals and nutrients.
3. Antioxidant Defense
As part of MnSOD, manganese helps neutralize free radicals, supporting cellular protection and healthy aging.
4. Improves Metabolic Function
Aids in the metabolism of carbohydrates, amino acids, and cholesterol, contributing to energy production and hormonal balance.
5. High Bioavailability and Solubility
The gluconate form offers good absorption and tolerability, making it suitable for both dietary and pharmaceutical use.
Conclusion
Manganese gluconate (CAS 6485-39-8) is a bioavailable, water-soluble manganese supplement used in nutritional, pharmaceutical, veterinary, and agricultural applications. It plays a critical role in enzyme function, bone health, antioxidant protection, and metabolic regulation. With a strong safety profile at recommended doses and broad functionality, manganese gluconate is an essential ingredient in health-supporting formulations for both humans and animals.
