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Specifications
| Appearance | White to off-white powder |
| HNMR | Complies to structure |
| Assay (GC) | 98.0% min |
| E.E. (HPLC) | 99.0% min |
| Melting Point | 30-34 °C (lit.) |
| Boiling Point | 114-116 °C (10 mmHg) |
| Specific Rotation [α]20D / [α]25D | 37 ± 3 (c = 1, ethanol) |
| Water (KF) | 0.5% max |
Applications
(S)-tert-Leucinol is used as a valuable chiral building block in asymmetric synthesis, particularly for pharmaceuticals, agrochemicals, and fine chemicals. It serves as a precursor for producing chiral ligands, catalysts, and intermediates in the synthesis of active pharmaceutical ingredients (APIs) such as HIV protease inhibitors. It is also employed in stereoselective synthesis for introducing chirality into target molecules and in the development of advanced materials requiring enantiopure components.
Benefits
The compound offers high enantiomeric purity, which is essential for producing optically active molecules with desired biological activity. Its robust tert-butyl side chain provides steric control in synthesis, improving reaction selectivity and yield. Additionally, its stability and versatility make it suitable for various synthetic routes, reducing the number of purification steps and enhancing cost efficiency in manufacturing.
Conclusion
(S)-tert-Leucinol is a versatile, high-purity chiral intermediate that supports efficient and selective synthesis of complex molecules. Its ability to introduce precise stereochemistry makes it indispensable in modern drug development, specialty chemical production, and advanced material synthesis.
