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Specifications
| Appearance | White to off-white powder |
| Purity (HPLC) | 99.0% min |
| Identification | HPLC RT |
| Specific Rotation [α]D20 | -28.5° ~ -21.5° (C=1, DMF) |
| Water (K.F.) | 1.0% max |
Applications
FMOC-TRP(ME)-OH is a protected tryptophan derivative used extensively in solid-phase peptide synthesis (SPPS). The Fmoc (9-fluorenylmethyloxycarbonyl) group protects the amino terminus, while the methyl ester (ME) protects the indole side chain, allowing for selective deprotection and controlled peptide elongation. This compound is commonly employed in the synthesis of bioactive peptides, cyclic peptides, and therapeutic peptide analogs. It is also applied in research focused on peptide-based drug discovery, enzyme inhibitors, and biochemical probes that require precise incorporation of modified tryptophan residues.
Benefits
The benefits of FMOC-TRP(ME)-OH include its high chemical stability, solubility in organic solvents, and compatibility with a wide range of peptide coupling reagents. The dual protection strategy prevents undesired side reactions during multi-step synthesis, ensuring high yields and reproducibility. Incorporation of the tryptophan residue contributes to peptide functionality, such as fluorescence properties and structural stability, which are essential in biochemical studies and therapeutic applications. Its versatility facilitates efficient production of complex peptides and modified biomolecules with high precision.
Conclusion
FMOC-TRP(ME)-OH is a valuable intermediate in peptide synthesis, providing protection and stability for controlled incorporation of tryptophan residues. Its applications in SPPS, bioactive peptide development, and biochemical research, combined with its benefits of high stability and reactivity control, make it essential for advanced peptide chemistry. By enabling precise and efficient peptide construction, FMOC-TRP(ME)-OH continues to support innovation in drug discovery and biomolecular research.
