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Specifications
| Appearance | White to off-white powder |
| Purity (HPLC) | 98% min |
| Clarity of solution | 0.3 gram in 4 ml 1N HCl clear solution |
| Loss on drying | 2% max (80℃, 2h) |
| IR Spectrum | In accordance with the structure |
| Mass Spectrum | In accordance with the structure |
| NMR Spectrum | In accordance with the structure |
Applications
D(-)-4-Chlorophenylglycine is primarily used as a chiral building block in pharmaceutical and chemical research. It serves as a precursor in the synthesis of optically active amino acid derivatives, peptidomimetics, and enzyme inhibitors. This compound is particularly valuable in the development of central nervous system (CNS) drugs, including modulators of glutamate receptors, where the stereochemistry and aromatic substitution play a key role in biological activity. Additionally, it is used in asymmetric synthesis as a chiral auxiliary or ligand, enabling the production of enantiomerically pure compounds for drug discovery, medicinal chemistry, and fine chemical synthesis.
Benefits
The main benefits of D(-)-4-Chlorophenylglycine lie in its defined stereochemistry, high purity, and chemical versatility. Its D-enantiomeric configuration allows for selective interactions in chiral synthesis and biological studies, supporting the design of compounds with specific activity and minimal off-target effects. The 4-chloro substitution on the aromatic ring enhances chemical reactivity and enables further functionalization, making it a flexible intermediate for multi-step synthesis. Its stability and solubility properties ensure reliable performance in laboratory and industrial processes, streamlining the preparation of high-value enantiomerically pure molecules.
Conclusion
D(-)-4-Chlorophenylglycine is a valuable chiral amino acid intermediate for pharmaceutical research, asymmetric synthesis, and the development of biologically active molecules. Its stereochemical integrity and functionalized aromatic structure make it ideal for creating enantiomerically pure compounds, peptidomimetics, and CNS-active drugs. By providing precision, versatility, and reliability, it plays a critical role in modern medicinal chemistry and chemical synthesis.
