Hangzhou Leap Chem Co., Ltd. is one of the most professional manufacturers and suppliers of n-carbobenzyloxy-l-glutamine丨cas 2650-64-8 in China. Welcome to wholesale bulk high quality chemical products at competitive price from our factory. If you have any enquiry about custom service, please feel free to email us.
Specifications
| Appearance: | White to off-white microcrystalline powder |
| Assay: | 98% min |
| Melting Point (M.p): | 124 to 126℃ |
| Water Content: | 1.0% max |
| Loss on Drying (LOD, 105℃/Vac/3h): | 1.0% max |
| 1H NMR (300 MHz): | Consistent |
Applications
N-Carbobenzyloxy-L-glutamine is a protected amino acid derivative extensively used in peptide synthesis, medicinal chemistry, and biochemical research. The carbobenzyloxy (Cbz) group protects the amino functionality, allowing selective reactions at the carboxyl or side-chain groups without undesired side reactions. This compound serves as a key intermediate in the synthesis of L-glutamine-containing peptides, enzymes, and bioactive molecules. It is widely employed in the development of pharmaceutical compounds, including enzyme inhibitors and therapeutics targeting metabolic and neurological pathways. Additionally, N-Carbobenzyloxy-L-glutamine is utilized in solid-phase and solution-phase peptide synthesis, enabling precise construction of complex peptide sequences and functionalized derivatives for research and drug development.
Benefits
The Cbz protection offers significant advantages in multi-step synthesis by preventing side reactions and preserving stereochemistry. N-Carbobenzyloxy-L-glutamine is chemically stable, soluble in organic solvents, and compatible with various coupling reagents and reaction conditions. Its use allows high-yield, reproducible reactions in peptide assembly, ensuring retention of the L-glutamine configuration. The compound also enables selective deprotection under mild conditions, providing free amino acids or peptides for further modification. Its versatility, high purity, and reliability make it an essential building block in pharmaceutical research, peptide engineering, and the synthesis of bioactive molecules.
Conclusion
N-Carbobenzyloxy-L-glutamine is a crucial protected amino acid intermediate for peptide synthesis and drug development. Its Cbz-protected amino group ensures stability, selectivity, and versatility, supporting the efficient creation of L-glutamine-containing peptides and bioactive compounds. By enabling precise, high-yield synthesis, this compound continues to facilitate advances in medicinal chemistry, peptide research, and biochemical studies.
