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Specifications
| Appearance: | Gray black liquid |
| Concentration (Titration): | 2.80M–3.30M in THF |
| Assay: | 20.5% to 24.0% |
Transport Information
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Parameter |
Specification |
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UN Number |
3099 |
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Class |
4.3 (3) |
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Packing Group |
I |
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H.S. Code |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
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Storage |
Tightly closed. Store in a closed, dry, ventilated place |
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Condition to Avoid |
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Package |
Manufacturing Information
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Parameter |
Specification |
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Capacity |
10MT/month |
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Frequency |
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Main Export Countries |
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Capacity/Batch |
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Experience |
Production since 2005 |
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Stock |
Applications
1. Nucleophilic Addition to Carbonyl Compounds
Reacts with aldehydes, ketones, esters, and acid chlorides to form alcohols after protonation.
For example, reaction with formaldehyde produces primary alcohols, while ketones yield tertiary alcohols.
Enables the introduction of a methyl group at the electrophilic site, a key step in fine chemical and pharmaceutical synthesis.
2. Synthesis of Pharmaceuticals and Agrochemicals
Used extensively to install methyl groups in active pharmaceutical ingredients (APIs) and agrochemical intermediates, often improving biological activity or modifying physical properties.
3. Formation of Organometallic Intermediates
Participates in metal–halogen exchange and transmetallation reactions to prepare other organometallic species.
Useful in the synthesis of complex molecules through iterative functional group transformations.
4. Polymer Chemistry
Serves as a chain initiator or modifier in certain polymerization processes, such as anionic polymerization.
5. Research and Development
Utilized in laboratory-scale organic synthesis for the preparation of new compounds and optimization of synthetic routes.
Benefits
1. High Reactivity
Reacts readily with a variety of electrophiles, facilitating efficient methyl group installation.
2. Wide Applicability
Applicable across many substrates including carbonyls, epoxides, and halides.
3. Scalability
Available commercially in bulk, suitable for both research scale and industrial production.
4. Reliable and Well-Studied
Well-characterized reagent with predictable outcomes in synthetic chemistry.
Conclusion
Methylmagnesium chloride (CAS 676-58-4) is a fundamental Grignard reagent used to introduce methyl groups into organic molecules via nucleophilic addition to electrophilic centers. Its broad use in pharmaceutical, agrochemical, and polymer industries stems from its high reactivity, versatility, and availability. Careful handling and inert conditions are critical to safely harness its powerful synthetic capabilities.
