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Specifications
| Appearance: | White to off-white or gray powder |
| Assay: | 95% min. |
Transport Information
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Parameter |
Specification |
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UN Number |
1390/1412 |
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Class |
4.3 |
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Packing Group |
II |
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H.S. Code |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
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Storage |
Tightly closed. Store in a closed, dry, ventilated place |
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Condition to Avoid |
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Package |
Manufacturing Information
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Parameter |
Specification |
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Capacity |
10MT/month |
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Frequency |
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Main Export Countries |
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Capacity/Batch |
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Experience |
Production since 2005 |
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Stock |
Applications
1. Strong Non-Nucleophilic Base
Lithium amide serves as a powerful base for deprotonation reactions, particularly in situations requiring strong and non-nucleophilic bases.
Widely used in the preparation of carbanions and organolithium intermediates.
2. Synthesis of Organolithium Compounds
Employed to generate organolithium species by deprotonating weakly acidic C–H bonds or by metal–halogen exchange.
Acts as a precursor for other lithium reagents used in carbon–carbon bond formation.
3. Ammonia Synthesis and Hydrogen Storage
Lithium amide can play a role in advanced ammonia synthesis processes under certain catalytic systems.
Investigated for potential use in hydrogen storage materials due to reversible ammonia synthesis and decomposition.
4. Dehydrohalogenation and Elimination Reactions
Utilized to promote elimination of hydrogen halides (HX) from alkyl halides to form alkenes or alkynes.
Provides mild yet effective reaction conditions for elimination over substitution.
5. Polymer Chemistry
Used in the synthesis of polyamides and polyimides as a reagent or catalyst.
Acts as a strong base in polymerization and polymer modification processes.
Benefits
1. Extremely Strong Basicity
Offers very high basic strength, capable of deprotonating weakly acidic substrates inaccessible to other bases.
2. Selective and Clean Reactions
Lithium amide often provides high selectivity with minimal side reactions due to its non-nucleophilic nature.
3. High Reactivity
Reacts rapidly under controlled conditions, enabling efficient synthetic transformations.
4. Versatility
Used across various reaction types including deprotonation, elimination, and organolithium formation.
Conclusion
Lithium amide (CAS 7782-89-0) is a potent inorganic base used extensively in organic synthesis for deprotonation, elimination reactions, and organolithium compound preparation. Its strong basicity, selectivity, and high reactivity make it a valuable reagent in pharmaceutical, polymer, and industrial chemical synthesis. Proper handling under inert, dry conditions is essential due to its reactivity and sensitivity.
